General Information of the Compound
Compound ID
CP0420523
Compound Name
2,6-diphenyl-9H-purine
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Synonyms
1H-Purine, 2,6-diphenyl-
2,6-diphenyl-9H-purine
889673-58-9
CHEMBL381729
CTK3A4137
DTXSID90468791
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Structure
Formula
C17H12N4
Molecular Weight
272.311
Canonical SMILES
c1nc2nc(nc(-c3ccccc3)c2[nH]1)-c1ccccc1
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InChI
InChI=1S/C17H12N4/c1-3-7-12(8-4-1)14-15-17(19-11-18-15)21-16(20-14)13-9-5-2-6-10-13/h1-11H,(H,18,19,20,21)
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InChIKey
WNVFFQZYOFELQA-UHFFFAOYSA-N
Physicochemical Property
logP
3.6869
Rotatable Bonds
2
Heavy Atom Count
21
Polar Areas
54.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11572592
SID: 16674893
ChEMBL ID
CHEMBL381729
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 53 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 38 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 2,6-diphenyl-9H-purine )
Drug Name 2,6-diphenyl-9H-purine
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor
Adenosine A3 receptor (ADORA3)
Inhibitor