General Information of the Compound
Compound ID
CP0579700
Compound Name
2-amino-8-[(3-methoxyphenyl)methyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C19H17N5O3
Molecular Weight
363.377
Canonical SMILES
COc1cccc(Cn2c3nc(N)nc(-c4ccc(C)o4)c3ncc2=O)c1
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InChI
InChI=1S/C19H17N5O3/c1-11-6-7-14(27-11)16-17-18(23-19(20)22-16)24(15(25)9-21-17)10-12-4-3-5-13(8-12)26-2/h3-9H,10H2,1-2H3,(H2,20,22,23)
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InChIKey
YOLQTROSRYZZFQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.39402
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
109.06
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215463
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 475.7 nM
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