General Information of the Compound
Compound ID
CP0513771
Compound Name
2-(2,6-difluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
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Structure
Formula
C21H22F2N4O4S
Molecular Weight
464.494
Canonical SMILES
COc1cnc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3c(F)cccc3F)nc12
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InChI
InChI=1S/C21H22F2N4O4S/c1-21(2,31-16-12(22)5-4-6-13(16)23)19(28)26-20-25-15-14(29-3)11-24-18(17(15)32-20)27-7-9-30-10-8-27/h4-6,11H,7-10H2,1-3H3,(H,25,26,28)
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InChIKey
DICYPAFHQOIAQH-UHFFFAOYSA-N
Physicochemical Property
logP
3.6108
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
85.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137659296
ChEMBL ID
CHEMBL4099543
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 15 nM
   TI
   LI
   LO
   TS
2
Ki = 26.5 nM
   TI
   LI
   LO
   TS