General Information of the Compound
Compound ID
CP0571546
Compound Name
2-amino-8-[2-[4-[2,3-difluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C26H29F2N7O4
Molecular Weight
541.559
Canonical SMILES
COCCOc1ccc(N2CCN(CCn3c4nc(N)nc(-c5ccc(C)o5)c4ncc3=O)CC2)c(F)c1F
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InChI
InChI=1S/C26H29F2N7O4/c1-16-3-5-19(39-16)23-24-25(32-26(29)31-23)35(20(36)15-30-24)12-9-33-7-10-34(11-8-33)17-4-6-18(22(28)21(17)27)38-14-13-37-2/h3-6,15H,7-14H2,1-2H3,(H2,29,31,32)
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InChIKey
PCTRWGZWJUJBDK-UHFFFAOYSA-N
Physicochemical Property
logP
2.46272
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
124.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215433
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 9.3 nM
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