General Information of the Compound
Compound ID
CP0483399
Compound Name
[4-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-2-nitrophenyl] 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
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Structure
Formula
C39H47N11O10S
Molecular Weight
861.939
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCc3ccc(CCC(=O)Nc4ccc(OC(=O)CCCC[C@@H]5SC[C@@H]6NC(=O)N[C@H]56)c(c4)[N+]([O-])=O)cc3)nc12
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InChI
InChI=1S/C39H47N11O10S/c1-2-41-36(55)33-31(53)32(54)37(60-33)49-19-43-30-34(40)47-38(48-35(30)49)42-16-15-21-9-7-20(8-10-21)11-14-27(51)44-22-12-13-25(24(17-22)50(57)58)59-28(52)6-4-3-5-26-29-23(18-61-26)45-39(56)46-29/h7-10,12-13,17,19,23,26,29,31-33,37,53-54H,2-6,11,14-16,18H2,1H3,(H,41,55)(H,44,51)(H2,45,46,56)(H3,40,42,47,48)/t23-,26-,29-,31-,32+,33-,37+/m0/s1
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InChIKey
MUXUIVVLQXFMRX-CXJTVLAKSA-N
Physicochemical Property
logP
1.9291
Rotatable Bonds
18
Heavy Atom Count
61
Polar Areas
300.11
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
17
Complexity
61

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118714542
ChEMBL ID
CHEMBL3335525
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3280 nM
   TI
   LI
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   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1960 nM
   TI
   LI
   LO
   TS