General Information of the Compound
Compound ID
CP0398961
Compound Name
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[4-(methanesulfonamido)phenyl]acetamide
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Structure
Formula
C23H24N6O4S
Molecular Weight
480.55
Canonical SMILES
Cc1cc(C)n(n1)-c1cc(NC(=O)Cc2ccc(NS(C)(=O)=O)cc2)nc(n1)-c1ccc(C)o1
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InChI
InChI=1S/C23H24N6O4S/c1-14-11-15(2)29(27-14)21-13-20(25-23(26-21)19-10-5-16(3)33-19)24-22(30)12-17-6-8-18(9-7-17)28-34(4,31)32/h5-11,13,28H,12H2,1-4H3,(H,24,25,26,30)
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InChIKey
CJMZMTPUYHISPT-UHFFFAOYSA-N
Physicochemical Property
logP
3.40026
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
132.01
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44454626
ChEMBL ID
CHEMBL257417
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5 nM
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