General Information of the Compound
Compound ID
CP0485897
Compound Name
9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
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Synonyms
496955-70-5
9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
9H-Purin-6-amine, 9-methyl-8-(2H-1,2,3-triazol-2-yl)-
BDBM50176057
CHEMBL194728
SCHEMBL4462539
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Structure
Formula
C8H8N8
Molecular Weight
216.208
Canonical SMILES
Cn1c(nc2c(N)ncnc12)-n1nccn1
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InChI
InChI=1S/C8H8N8/c1-15-7-5(6(9)10-4-11-7)14-8(15)16-12-2-3-13-16/h2-4H,1H3,(H2,9,10,11)
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InChIKey
ZTJZVOMEMRNYKF-UHFFFAOYSA-N
Physicochemical Property
logP
-0.4738
Rotatable Bonds
1
Heavy Atom Count
16
Polar Areas
100.33
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
16

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9877796
SID: 14843591
ChEMBL ID
CHEMBL194728
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 46.3 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine )
Drug Name 9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor