General Information of the Compound
Compound ID
CP0504997
Compound Name
2-(3,4-difluorophenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
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Structure
Formula
C22H19F2N5O2
Molecular Weight
423.423
Canonical SMILES
Cc1cc(C)n(n1)-c1cc(NC(=O)Cc2ccc(F)c(F)c2)nc(n1)-c1ccc(C)o1
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InChI
InChI=1S/C22H19F2N5O2/c1-12-8-13(2)29(28-12)20-11-19(26-22(27-20)18-7-4-14(3)31-18)25-21(30)10-15-5-6-16(23)17(24)9-15/h4-9,11H,10H2,1-3H3,(H,25,26,27,30)
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InChIKey
RSMDEAIXWSAVMJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.30696
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
85.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44454781
ChEMBL ID
CHEMBL255569
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5 nM
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