General Information of the Compound
Compound ID
CP0575725
Compound Name
2-amino-4-(5-methylfuran-2-yl)-8-[2-(4-methylpiperazin-1-yl)ethyl]pteridin-7-one
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Structure
Formula
C18H23N7O2
Molecular Weight
369.429
Canonical SMILES
CN1CCN(CCn2c3nc(N)nc(-c4ccc(C)o4)c3ncc2=O)CC1
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InChI
InChI=1S/C18H23N7O2/c1-12-3-4-13(27-12)15-16-17(22-18(19)21-15)25(14(26)11-20-16)10-9-24-7-5-23(2)6-8-24/h3-4,11H,5-10H2,1-2H3,(H2,19,21,22)
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InChIKey
DYBIIASEQSAQKZ-UHFFFAOYSA-N
Physicochemical Property
logP
0.58452
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
106.31
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215452
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
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