General Information of the Compound
Compound ID
CP0534013
Compound Name
2-amino-8-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C26H31N7O4
Molecular Weight
505.579
Canonical SMILES
COCCOc1ccc(cc1)N1CCN(CCn2c3nc(N)nc(-c4ccc(C)o4)c3ncc2=O)CC1
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InChI
InChI=1S/C26H31N7O4/c1-18-3-8-21(37-18)23-24-25(30-26(27)29-23)33(22(34)17-28-24)14-11-31-9-12-32(13-10-31)19-4-6-20(7-5-19)36-16-15-35-2/h3-8,17H,9-16H2,1-2H3,(H2,27,29,30)
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InChIKey
ONAMVEAIHJHYNG-UHFFFAOYSA-N
Physicochemical Property
logP
2.18452
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
124.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166635240
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 23.8 nM
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