General Information of the Compound
Compound ID
CP0198681
Compound Name
2-amino-N-[(4-ethoxyquinolin-8-yl)methyl]-8-fluoroquinazoline-4-carboxamide
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Structure
Formula
C21H18FN5O2
Molecular Weight
391.406
Canonical SMILES
CCOc1ccnc2c(CNC(=O)c3nc(N)nc4c(F)cccc34)cccc12
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InChI
InChI=1S/C21H18FN5O2/c1-2-29-16-9-10-24-17-12(5-3-6-13(16)17)11-25-20(28)19-14-7-4-8-15(22)18(14)26-21(23)27-19/h3-10H,2,11H2,1H3,(H,25,28)(H2,23,26,27)
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InChIKey
IXOYUGLITMOWAV-UHFFFAOYSA-N
Physicochemical Property
logP
3.228
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
103.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127041636
ChEMBL ID
CHEMBL3764812
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 252 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 73.2 nM
   TI
   LI
   LO
   TS