General Information of the Compound
Compound ID
CP0054094
Compound Name
Binodenoson
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Synonyms
Binodenoson
CorVue
MRE-0470
MRE-0479
MRE-470
SHA-174
WRC-0470
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Structure
Formula
C17H25N7O4
Molecular Weight
391.432
Canonical SMILES
Nc1nc(N\N=C\C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
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InChI
InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1
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InChIKey
XJFMHMFFBSOEPR-DNZQAUTHSA-N
CAS
144348-08-3
Physicochemical Property
logP
-0.002
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
163.93
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
11
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9576912
SID: 14756535
ChEMBL ID
CHEMBL1950554
DrugBank ID
DB04853
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 169 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 48000 nM
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 81 nM
   TI
   LI
   LO
   TS
2
Ki = 270 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 270 nM
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 > 100000 nM
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 52.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 903 nM
Clinical Information about the Compound
Drug 1 ( Binodenoson )
Drug Name Binodenoson
Company Aderis Pharmaceuticals Inc
Indication
Hypertension
Phase 3
Target(s)
Adenosine A2a receptor (ADORA2A)
Agonist