General Information of the Compound
Compound ID
CP0461220
Compound Name
(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(beta-aminoethyl-Naminoethylaminocarbonyl)-1-butanyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
    Show/Hide
Structure
Formula
C29H36ClN9O4
Molecular Weight
610.119
Canonical SMILES
CNC(=O)[C@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3cccc(Cl)c3)nc(nc12)C#CCCC(=O)NCCNCCN
    Show/Hide
InChI
InChI=1S/C29H36ClN9O4/c1-32-28(43)29-14-19(29)23(24(41)25(29)42)39-16-36-22-26(35-15-17-5-4-6-18(30)13-17)37-20(38-27(22)39)7-2-3-8-21(40)34-12-11-33-10-9-31/h4-6,13,16,19,23-25,33,41-42H,3,8-12,14-15,31H2,1H3,(H,32,43)(H,34,40)(H,35,37,38)/t19-,23-,24+,25+,29-/m1/s1
    Show/Hide
InChIKey
NRUJZDKFSIKSAB-SDSNXHIZSA-N
Physicochemical Property
logP
-0.0832
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
192.34
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
11
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45483965
ChEMBL ID
CHEMBL583746
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 890 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 15.4 nM
   TI
   LI
   LO
   TS