General Information of the Compound
Compound ID
CP0573884
Compound Name
2-amino-8-[2-[4-[2-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C26H30FN7O4
Molecular Weight
523.569
Canonical SMILES
COCCOc1ccc(N2CCN(CCn3c4nc(N)nc(-c5ccc(C)o5)c4ncc3=O)CC2)c(F)c1
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InChI
InChI=1S/C26H30FN7O4/c1-17-3-6-21(38-17)23-24-25(31-26(28)30-23)34(22(35)16-29-24)12-9-32-7-10-33(11-8-32)20-5-4-18(15-19(20)27)37-14-13-36-2/h3-6,15-16H,7-14H2,1-2H3,(H2,28,30,31)
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InChIKey
OCQPYNZYCWMACM-UHFFFAOYSA-N
Physicochemical Property
logP
2.32362
Rotatable Bonds
9
Heavy Atom Count
38
Polar Areas
124.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215450
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 7.9 nM
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