General Information of the Compound
Compound ID
CP0541171
Compound Name
5-amino-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
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Structure
Formula
C25H30N10O3S
Molecular Weight
550.649
Canonical SMILES
COCCOc1ccc(cc1)N1CCN(CCn2c3nc(N)n4nc(nc4c3n(C)c2=O)-c2nccs2)CC1
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InChI
InChI=1S/C25H30N10O3S/c1-31-19-21(29-24(26)35-22(19)28-20(30-35)23-27-7-16-39-23)34(25(31)36)13-10-32-8-11-33(12-9-32)17-3-5-18(6-4-17)38-15-14-37-2/h3-7,16H,8-15H2,1-2H3,(H2,26,29)
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InChIKey
MGFKXUGZODTPSK-UHFFFAOYSA-N
Physicochemical Property
logP
1.3308
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
133.86
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
14
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56943872
SID: 135646181
ChEMBL ID
CHEMBL4208426
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 1.2 nM
   TI
   LI
   LO
   TS
2
Ki = 6.4 nM
   TI
   LI
   LO
   TS