General Information of the Compound
Compound ID
CP0533396
Compound Name
3-cyano-N-(3-(4-methoxybenzyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
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Structure
Formula
C28H26N6O3
Molecular Weight
494.555
Canonical SMILES
COc1ccc(Cn2c(NC(=O)c3cccc(c3)C#N)nc3cc(cnc23)C(=O)N2CCCCC2)cc1
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InChI
InChI=1S/C28H26N6O3/c1-37-23-10-8-19(9-11-23)18-34-25-24(15-22(17-30-25)27(36)33-12-3-2-4-13-33)31-28(34)32-26(35)21-7-5-6-20(14-21)16-29/h5-11,14-15,17H,2-4,12-13,18H2,1H3,(H,31,32,35)
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InChIKey
LCFAEAFTUJEECB-UHFFFAOYSA-N
Physicochemical Property
logP
4.23828
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
113.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52946949
ChEMBL ID
CHEMBL1271121
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1220 nM
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