General Information of the Compound
Compound ID
CP0422897
Compound Name
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-(4-methylphenyl)piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
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Structure
Formula
C24H27N9O2
Molecular Weight
473.541
Canonical SMILES
Cc1ccc(cc1)N1CCN(CCn2c3nc(N)n4nc(nc4c3n(C)c2=O)-c2ccco2)CC1
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InChI
InChI=1S/C24H27N9O2/c1-16-5-7-17(8-6-16)31-12-9-30(10-13-31)11-14-32-21-19(29(2)24(32)34)22-26-20(18-4-3-15-35-18)28-33(22)23(25)27-21/h3-8,15H,9-14H2,1-2H3,(H2,25,27)
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InChIKey
KQLMKDVBZAWJSH-UHFFFAOYSA-N
Physicochemical Property
logP
1.75052
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
115.65
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56943870
SID: 135646179
ChEMBL ID
CHEMBL4218105
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
2
Ki = 1.4 nM
   TI
   LI
   LO
   TS