General Information of the Compound
Compound ID
CP0519764
Compound Name
2-amino-8-methoxy-N-[(5-methoxypyridin-2-yl)methyl]quinazoline-4-carboxamide
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Structure
Formula
C17H17N5O3
Molecular Weight
339.355
Canonical SMILES
COc1ccc(CNC(=O)c2nc(N)nc3c(OC)cccc23)nc1
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InChI
InChI=1S/C17H17N5O3/c1-24-11-7-6-10(19-9-11)8-20-16(23)15-12-4-3-5-13(25-2)14(12)21-17(18)22-15/h3-7,9H,8H2,1-2H3,(H,20,23)(H2,18,21,22)
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InChIKey
MDOJLXHRFIJLOH-UHFFFAOYSA-N
Physicochemical Property
logP
1.5542
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
112.25
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122444964
ChEMBL ID
CHEMBL3892905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 7.8 nM
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