General Information of the Compound
Compound ID
CP0279078
Compound Name
2-amino-8-fluoro-N-[[3-[methyl(3-pyridin-2-ylpropyl)carbamoyl]quinolin-8-yl]methyl]quinazoline-4-carboxamide
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Structure
Formula
C29H26FN7O2
Molecular Weight
523.572
Canonical SMILES
CN(CCCc1ccccn1)C(=O)c1cnc2c(CNC(=O)c3nc(N)nc4c(F)cccc34)cccc2c1
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InChI
InChI=1S/C29H26FN7O2/c1-37(14-6-10-21-9-2-3-13-32-21)28(39)20-15-18-7-4-8-19(24(18)33-17-20)16-34-27(38)26-22-11-5-12-23(30)25(22)35-29(31)36-26/h2-5,7-9,11-13,15,17H,6,10,14,16H2,1H3,(H,34,38)(H2,31,35,36)
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InChIKey
XFDPYXCMDIVHGP-UHFFFAOYSA-N
Physicochemical Property
logP
3.9291
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
126.99
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127041935
ChEMBL ID
CHEMBL3763871
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 210 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 12 nM
   TI
   LI
   LO
   TS