General Information of the Compound
Compound ID
CP0123209
Compound Name
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-pyridin-2-ylpyrimidin-4-amine
    Show/Hide
Structure
Formula
C20H25N7O
Molecular Weight
379.468
Canonical SMILES
COC[C@H]1CCCN1c1cc(Nc2ccccn2)nc(n1)-n1nc(C)cc1C
    Show/Hide
InChI
InChI=1S/C20H25N7O/c1-14-11-15(2)27(25-14)20-23-18(22-17-8-4-5-9-21-17)12-19(24-20)26-10-6-7-16(26)13-28-3/h4-5,8-9,11-12,16H,6-7,10,13H2,1-3H3,(H,21,22,23,24)/t16-/m1/s1
    Show/Hide
InChIKey
CPTFLTJFGWOVRS-MRXNPFEDSA-N
Physicochemical Property
logP
3.03294
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
80.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 72945115
ChEMBL ID
CHEMBL3098225
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 45 nM
   TI
   LI
   LO
   TS