General Information of the Compound
Compound ID
CP0498979
Compound Name
6-Furan-2-yl-9-(2,4,6-trifluoro-benzyl)-9H-purin-2-ylamine
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Structure
Formula
C16H10F3N5O
Molecular Weight
345.284
Canonical SMILES
Nc1nc(-c2ccco2)c2ncn(Cc3c(F)cc(F)cc3F)c2n1
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InChI
InChI=1S/C16H10F3N5O/c17-8-4-10(18)9(11(19)5-8)6-24-7-21-14-13(12-2-1-3-25-12)22-16(20)23-15(14)24/h1-5,7H,6H2,(H2,20,22,23)
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InChIKey
XSKSCOIXJWVHNE-UHFFFAOYSA-N
Physicochemical Property
logP
3.1341
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
82.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44401764
ChEMBL ID
CHEMBL372928
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 26 nM
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   LI
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