General Information of the Compound
Compound ID
CP0795220
Compound Name
US9227979, 3
    Show/Hide
Structure
Formula
C36H29N9O6S
Molecular Weight
715.752
Canonical SMILES
Cn1cc2c(nc(NCCCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)n3nc(-c4ccco4)nc23)n1
    Show/Hide
InChI
InChI=1S/C36H29N9O6S/c1-44-18-26-31(42-44)41-35(45-33(26)40-32(43-45)27-5-4-14-50-27)37-12-2-3-13-38-36(52)39-19-6-9-22(25(15-19)34(48)49)30-23-10-7-20(46)16-28(23)51-29-17-21(47)8-11-24(29)30/h4-11,14-18,46H,2-3,12-13H2,1H3,(H,48,49)(H,37,41,42)(H2,38,39,52)
    Show/Hide
InChIKey
LCOCYLSQCMDGHJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.7317
Rotatable Bonds
10
Heavy Atom Count
52
Polar Areas
197.87
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
13
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 123131616
ChEMBL ID
CHEMBL3949028
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1750 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 460 nM
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5660 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 720 nM