General Information of the Compound
Compound ID
CP0573105
Compound Name
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-(4-phenoxyphenyl)piperazin-1-yl]ethyl]pteridin-7-one
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Structure
Formula
C29H29N7O3
Molecular Weight
523.597
Canonical SMILES
Cc1ccc(o1)-c1nc(N)nc2n(CCN3CCN(CC3)c3ccc(Oc4ccccc4)cc3)c(=O)cnc12
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InChI
InChI=1S/C29H29N7O3/c1-20-7-12-24(38-20)26-27-28(33-29(30)32-26)36(25(37)19-31-27)18-15-34-13-16-35(17-14-34)21-8-10-23(11-9-21)39-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,30,32,33)
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InChIKey
WALHSXGJSVIXLF-UHFFFAOYSA-N
Physicochemical Property
logP
3.95162
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215449
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 604.8 nM
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