General Information of the Compound
Compound ID
CP0902331
Compound Name
5-(3-(3-(2-(2-(3-((2-(Furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e]-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)amino)propoxy)ethoxy)-ethoxy)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
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Structure
Formula
C42H41N9O9S
Molecular Weight
847.911
Canonical SMILES
Cn1cc2c(nc(NCCCOCCOCCOCCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)n3nc(-c4ccco4)nc23)n1
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InChI
InChI=1S/C42H41N9O9S/c1-50-24-32-37(48-50)47-41(51-39(32)46-38(49-51)33-5-2-16-59-33)43-12-3-14-56-17-19-58-20-18-57-15-4-13-44-42(61)45-25-6-9-28(31(21-25)40(54)55)36-29-10-7-26(52)22-34(29)60-35-23-27(53)8-11-30(35)36/h2,5-11,16,21-24,52H,3-4,12-15,17-20H2,1H3,(H,54,55)(H,43,47,48)(H2,44,45,61)
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InChIKey
LUPSHLDLDDIQJU-UHFFFAOYSA-N
Physicochemical Property
logP
5.7815
Rotatable Bonds
19
Heavy Atom Count
61
Polar Areas
225.56
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
16
Complexity
61

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155537874
ChEMBL ID
CHEMBL4475922
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 6010 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 7090 nM
   TI
   LI
   LO
   TS