General Information of the Compound
Compound ID
CP0418028
Compound Name
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-(2-(6-(1-(adamantyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
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Structure
Formula
C38H44ClN9O3
Molecular Weight
710.283
Canonical SMILES
CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3cccc(Cl)c3)nc(nc12)C#CCCCCc1cn(nn1)C12CC3CC(CC(C3)C1)C2
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InChI
InChI=1S/C38H44ClN9O3/c1-40-36(51)38-18-28(38)31(32(49)33(38)50)47-21-42-30-34(41-19-22-7-6-8-26(39)14-22)43-29(44-35(30)47)10-5-3-2-4-9-27-20-48(46-45-27)37-15-23-11-24(16-37)13-25(12-23)17-37/h6-8,14,20-21,23-25,28,31-33,49-50H,2-4,9,11-13,15-19H2,1H3,(H,40,51)(H,41,43,44)/t23?,24?,25?,28-,31-,32+,33+,37?,38+/m1/s1
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InChIKey
IMOUNXQRZGLBSG-DYHDFLJKSA-N
Physicochemical Property
logP
4.4019
Rotatable Bonds
10
Heavy Atom Count
51
Polar Areas
155.9
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
11
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46230556
ChEMBL ID
CHEMBL605399
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3280 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6.5 nM
   TI
   LI
   LO
   TS