General Information of the Compound
Compound ID
CP0381593
Compound Name
(R,S)-3-(3-(6-(ethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1-hydroxyprop-2-ynyl)benzoic acid
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Structure
Formula
C24H26N6O7
Molecular Weight
510.507
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCC)nc(nc12)C#CC(O)c1cccc(c1)C(O)=O
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InChI
InChI=1S/C24H26N6O7/c1-3-25-20-16-21(30(11-27-16)23-18(33)17(32)19(37-23)22(34)26-4-2)29-15(28-20)9-8-14(31)12-6-5-7-13(10-12)24(35)36/h5-7,10-11,14,17-19,23,31-33H,3-4H2,1-2H3,(H,26,34)(H,35,36)(H,25,28,29)/t14?,17-,18+,19-,23+/m0/s1
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InChIKey
PIJFDUYGIMMLFG-PCUSSDDASA-N
Physicochemical Property
logP
-0.2033
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
191.95
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
11
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44410559
ChEMBL ID
CHEMBL205946
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 131 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3783 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 20.1 nM
   TI
   LI
   LO
   TS