General Information of the Compound
Compound ID
CP0212778
Compound Name
2-amino-8-fluoro-N-[[3-(5-phenylpentylcarbamoyl)quinolin-8-yl]methyl]quinazoline-4-carboxamide
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Structure
Formula
C31H29FN6O2
Molecular Weight
536.611
Canonical SMILES
Nc1nc(C(=O)NCc2cccc3cc(cnc23)C(=O)NCCCCCc2ccccc2)c2cccc(F)c2n1
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InChI
InChI=1S/C31H29FN6O2/c32-25-15-8-14-24-27(25)37-31(33)38-28(24)30(40)36-18-22-13-7-12-21-17-23(19-35-26(21)22)29(39)34-16-6-2-5-11-20-9-3-1-4-10-20/h1,3-4,7-10,12-15,17,19H,2,5-6,11,16,18H2,(H,34,39)(H,36,40)(H2,33,37,38)
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InChIKey
UVHNHXMAXCQYMP-UHFFFAOYSA-N
Physicochemical Property
logP
4.9721
Rotatable Bonds
10
Heavy Atom Count
40
Polar Areas
122.89
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127041936
ChEMBL ID
CHEMBL3765424
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 160 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 6.9 nM
   TI
   LI
   LO
   TS