General Information of the Compound
Compound ID
CP0395703
Compound Name
methyl 1-[6-(dicyclopropylmethylamino)-9-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-2-bicyclo[3.1.0]hexanyl]purin-2-yl]pyrazole-4-carboxylate
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Structure
Formula
C23H27N7O4
Molecular Weight
465.514
Canonical SMILES
COC(=O)c1cnn(c1)-c1nc(NC(C2CC2)C2CC2)c2ncn([C@@H]3[C@H]4C[C@H]4[C@@H](O)[C@H]3O)c2n1
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InChI
InChI=1S/C23H27N7O4/c1-34-22(33)12-7-25-30(8-12)23-27-20(26-15(10-2-3-10)11-4-5-11)16-21(28-23)29(9-24-16)17-13-6-14(13)18(31)19(17)32/h7-11,13-15,17-19,31-32H,2-6H2,1H3,(H,26,27,28)/t13-,14+,17+,18+,19-/m0/s1
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InChIKey
YBDZYTKFWCAUDK-MFVLPEOLSA-N
Physicochemical Property
logP
1.3117
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
140.21
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
11
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71451659
ChEMBL ID
CHEMBL2170798
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 730 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 4110 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 490 nM
   TI
   LI
   LO
   TS