General Information of the Compound
Compound ID
CP0441349
Compound Name
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cyclohexylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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Structure
Formula
C17H22ClN5O2
Molecular Weight
363.849
Canonical SMILES
O[C@@H]1[C@@H]2C[C@@H]2[C@H]([C@@H]1O)n1cnc2c(NC3CCCCC3)nc(Cl)nc12
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InChI
InChI=1S/C17H22ClN5O2/c18-17-21-15(20-8-4-2-1-3-5-8)11-16(22-17)23(7-19-11)12-9-6-10(9)13(24)14(12)25/h7-10,12-14,24-25H,1-6H2,(H,20,21,22)/t9-,10+,12+,13+,14-/m0/s1
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InChIKey
FWCAXXBWEDQGJG-HNTFPEDGSA-N
Physicochemical Property
logP
2.1369
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
96.09
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70685288
ChEMBL ID
CHEMBL2012675
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 140 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2720 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 500 nM
   TI
   LI
   LO
   TS