General Information of the Compound
Compound ID
CP0123210
Compound Name
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-(2,2,2-trifluoroethyl)pyrimidin-4-amine
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Structure
Formula
C17H23F3N6O
Molecular Weight
384.406
Canonical SMILES
COC[C@H]1CCCN1c1cc(NCC(F)(F)F)nc(n1)-n1nc(C)cc1C
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InChI
InChI=1S/C17H23F3N6O/c1-11-7-12(2)26(24-11)16-22-14(21-10-17(18,19)20)8-15(23-16)25-6-4-5-13(25)9-27-3/h7-8,13H,4-6,9-10H2,1-3H3,(H,21,22,23)/t13-/m1/s1
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InChIKey
XNCPZNBFPUTRIL-CYBMUJFWSA-N
Physicochemical Property
logP
2.86854
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
68.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72945114
ChEMBL ID
CHEMBL3098224
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 24 nM
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   LI
   LO
   TS