| Compound ID |
Compound Name |
Compound Formula |
|
CP0334663
|
2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl)-N-(2-fluoroethyl)-2-(1H-pyrazol-1-yl)acetamide
Show/Hide
|
C27H29F4N5O2
|
1
|
| 1 |
IC50 = 0.09 nM
|
|
|
|
CP0488873
|
(Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)methanone O-ethyl oxime
Show/Hide
|
C27H26F3N3O2
|
1
|
| 1 |
IC50 = 0.12 nM
|
|
|
|
CP0431196
|
2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl)-2-(1H-pyrazol-1-yl)acetamide
Show/Hide
|
C27H30F3N5O2
|
1
|
| 1 |
IC50 = 0.15 nM
|
|
|
|
CP0430887
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C30H30Cl2N4O
|
2
|
| 1 |
IC50 = 0.17 nM
|
|
|
| 2 |
Ki = 0.17 nM
|
|
|
|
CP0441496
|
(Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)methanone O-methyl oxime
Show/Hide
|
C26H24F3N3O2
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0879762
|
(Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)methanone oxime
Show/Hide
|
C25H22F3N3O2
|
1
|
| 1 |
IC50 = 0.26 nM
|
|
|
|
CP0469241
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C29H30Cl2N4O
|
2
|
| 1 |
IC50 = 0.31 nM
|
|
|
| 2 |
Ki = 0.31 nM
|
|
|
|
CP0491236
|
(Z)-(3,4-difluorophenyl)(5-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)pyridin-2-yl)methanone O-ethyl oxime
Show/Hide
|
C26H25F3N4O2
|
1
|
| 1 |
IC50 = 0.35 nM
|
|
|
|
CP0777302
|
[35S]-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(4-(methylsulfonyl)-2-oxopiperazin-1-yl)acetamide
Show/Hide
|
C30H37F3N4O5S
|
3
|
| 1 |
IC50 = 0.36 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
| 3 |
Ki = 0.18 nM
|
|
|
|
CP0421935
|
(+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4''-piperidine]-1''-yl)propyl)-2-(4-(methylsulfonyl)-2-oxopiperazin-1-yl)acetamide
Show/Hide
|
C30H37F3N4O5S
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0417496
|
4-(4-chlorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H26ClN3O
|
2
|
| 1 |
IC50 = 0.36 nM
|
|
|
| 2 |
IC50 = 7.6 nM
|
|
|
|
CP0428184
|
6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-2-naphthalenyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C28H24ClN3OS
|
1
|
| 1 |
IC50 = 0.39 nM
|
|
|
|
CP0497383
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C29H30Cl2N4O2
|
2
|
| 1 |
IC50 = 0.41 nM
|
|
|
| 2 |
Ki = 0.41 nM
|
|
|
|
CP0124792
|
6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H24ClN3O3S
|
1
|
| 1 |
IC50 = 0.5012 nM
|
|
|
|
CP0417497
|
4-(4-methoxyphenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C29H29N3O2
|
2
|
| 1 |
IC50 = 0.53 nM
|
|
|
| 2 |
IC50 = 4.3 nM
|
|
|
|
CP0383206
|
4-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H26FN3O
|
2
|
| 1 |
IC50 = 0.54 nM
|
|
|
| 2 |
IC50 = 2.8 nM
|
|
|
|
CP0545592
|
2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(2-oxopyrrolidin-1-yl)acetamide
Show/Hide
|
C29H34F3N3O3
|
1
|
| 1 |
IC50 = 0.71 nM
|
|
|
|
CP0501981
|
6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C24H19ClN4OS
|
1
|
| 1 |
IC50 = 0.74 nM
|
|
|
|
CP0417494
|
4-(4-chlorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H24ClN3O
|
2
|
| 1 |
IC50 = 0.74 nM
|
|
|
| 2 |
IC50 = 8.5 nM
|
|
|
|
CP0442434
|
6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-7,8-dihydro-2-naphthalenyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C28H26ClN3OS
|
1
|
| 1 |
IC50 = 0.75 nM
|
|
|
|
CP0417491
|
4-(4-fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)naphthalen-2-yl]benzamide
Show/Hide
|
C28H25FN2O
|
2
|
| 1 |
IC50 = 0.76 nM
|
|
|
| 2 |
IC50 = 9 nM
|
|
|
|
CP0419614
|
6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-7,8-dihydro-2-naphthalenyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H24ClN3OS
|
1
|
| 1 |
IC50 = 0.87 nM
|
|
|
|
CP0507861
|
2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(2-oxopiperazin-1-yl)acetamide
Show/Hide
|
C29H35F3N4O3
|
1
|
| 1 |
IC50 = 0.87 nM
|
|
|
|
CP0160877
|
1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-butyl]-3-(3,5-difluoro-phenyl)-urea
Show/Hide
|
C26H26F2N4O
|
1
|
| 1 |
IC50 = 0.88 nM
|
|
|
|
CP0459771
|
6-(4-chlorophenyl)-3-[2-(1-piperidinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H23ClN4OS
|
1
|
| 1 |
IC50 = 0.89 nM
|
|
|
|
CP0529796
|
6-(4-chlorophenyl)-3-[2-(1-pyrrolidinylmethyl)-1-benzothien-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H20ClN3OS2
|
1
|
| 1 |
IC50 = 0.91 nM
|
|
|
|
CP0172425
|
N-[4-methyl-2-(2-piperidin-1-ylethylamino)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C26H29F3N4O3
|
2
|
| 1 |
IC50 = 0.91 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0423539
|
4-(4-fluorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)-2H-chromen-7-yl]benzamide
Show/Hide
|
C27H25FN2O2
|
2
|
| 1 |
IC50 = 0.91 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0417495
|
4-(4-fluorophenyl)-N-[8-fluoro-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H23F2N3O
|
2
|
| 1 |
IC50 = 0.92 nM
|
|
|
| 2 |
IC50 = 2.3 nM
|
|
|
|
CP0461987
|
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
Show/Hide
|
C26H33ClN2O
|
2
|
| 1 |
IC50 = 0.96 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0151484
|
1-(3-Chloro-4-fluoro-phenyl)-3-[2-(3'-cyano-biphenyl-4-yl)-4-dimethylamino-butyl]-urea
Show/Hide
|
C26H26ClFN4O
|
2
|
| 1 |
IC50 = 0.98 nM
|
|
|
| 2 |
Ki = 0.98 nM
|
|
|
|
CP0498305
|
(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-phenylacetamide
Show/Hide
|
C30H32F2N2O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0529714
|
6-(4-chlorophenyl)-3-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H21ClN4OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0502824
|
6-(4-methoxyphenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C26H27N3O4S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0537613
|
2-(3,4-difluorophenyl)-N-ethyl-2-(2-oxopyrrolidin-1-yl)-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C29H35F2N3O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0139514
|
N-[3-[1-[3-[4-(3,4-difluorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H30F2N4O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0458174
|
4-(4-methylphenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C29H29N3O
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0386528
|
6-(4-chlorophenyl)-3-[1-methyl-2-(pyrrolidin-1-ylmethyl)-1Hindol-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H23ClN4OS
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0386536
|
6-(4-chlorophenyl)-3-{6-[(dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl}thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C25H24ClN3OS
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0428183
|
6-(4-methylphenyl)-3-[2-(pyrrolidin-1-ylmethyl)-1-benzofuran-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H20ClN3O2S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0383034
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(1R)-1-pyrrolidin-1-ylethyl]quinolin-7-yl]benzamide
Show/Hide
|
C27H31N3O2
|
2
|
| 1 |
IC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 2.9 nM
|
|
|
|
CP0912552
|
(E)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)methanone oxime
Show/Hide
|
C25H22F3N3O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0399411
|
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)butan-1-one
Show/Hide
|
C25H31ClN2O
|
2
|
| 1 |
IC50 = 1.2 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0106677
|
1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-butyl]-3-(3-fluoro-phenyl)-urea
Show/Hide
|
C26H27FN4O
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0434054
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclohexyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C32H34Cl2N4O
|
2
|
| 1 |
IC50 = 1.2 nM
|
|
|
| 2 |
Ki = 1.2 nM
|
|
|
|
CP0408360
|
6-(4-fluorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C25H24FN3O3S
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0439493
|
6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-5,6,7,8-tetrahydro-2-naphthalenyl]thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C27H26ClN3OS
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0528567
|
6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-1-benzothien-5-yl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H18ClN3OS2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0499923
|
6-(4-chlorophenyl)-3-{2-[(4-phenyl-1-piperidinyl)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C33H27ClN4OS
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0339220
|
N-[4-methyl-2-(2-morpholin-4-ylethylamino)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O4
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0419052
|
3,4-difluoro-N-(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)-N-methylaniline
Show/Hide
|
C25H24F3N3O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0416915
|
4-(4-fluorophenyl)-N-[6-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H26FN3O
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0475742
|
4-(2-cyclopropylethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H31N3O2
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 2 nM
|
|
|
|
CP0518079
|
6-(4-chlorophenyl)-3-(2-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-1-methyl-1H-indol-5-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C28H27ClN4O2S
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0535090
|
(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)methanone
Show/Hide
|
C25H21F3N2O2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0059470
|
2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-6-yl)acetamide
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0436866
|
4-[(4-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one
Show/Hide
|
C24H25ClN2O3
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0498841
|
4-(4-chlorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C28H27ClN2O
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 4.8 nM
|
|
|
|
CP0416914
|
N-[6-chloro-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-4-(4-fluorophenyl)benzamide
Show/Hide
|
C27H23ClFN3O
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0460839
|
4-(4-fluorophenyl)-N-[6-fluoro-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H23F2N3O
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 8.4 nM
|
|
|
|
CP0518096
|
6-(4-chlorophenyl)-3-[2-({4-[2-(1-pyrrolidinyl)ethyl]-1-piperidinyl}methyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C33H34ClN5OS
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0515596
|
4-(cyclopropylmethoxy)-N-[3-[1-[(2-hydroxy-2-methylpropyl)amino]ethyl]-8-methylquinolin-7-yl]benzamide
Show/Hide
|
C27H33N3O3
|
2
|
| 1 |
IC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 6.4 nM
|
|
|
|
CP0526881
|
N-[3-[(1R)-1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
Show/Hide
|
C27H32N4O3
|
2
|
| 1 |
IC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 4.7 nM
|
|
|
|
CP0505655
|
6-(4-chlorophenyl)-3-[1-(3-hydroxypropyl)-2-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C23H19ClN4O2S
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0541281
|
6-(4-chlorophenyl)-3-[2-(dimethylamino)-3-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C22H18ClN5OS
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0385999
|
6-(3,4-dichlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C25H23Cl2N3O3S
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0526610
|
4-(4-methylphenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C29H30N2O
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0474043
|
(+/-)-N-(3-(3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(1H-pyrazol-1-yl)acetamide
Show/Hide
|
C28H31F2N3O2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0339219
|
N-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O4
|
2
|
| 1 |
IC50 = 1.7 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0494822
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-(1-pyrrolidin-1-ylethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H31N3O2
|
2
|
| 1 |
IC50 = 1.7 nM
|
|
|
| 2 |
IC50 = 6.4 nM
|
|
|
|
CP0425471
|
4-(4-chlorophenyl)-N-[6-[(dimethylamino)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C26H25ClN2O
|
2
|
| 1 |
IC50 = 1.8 nM
|
|
|
| 2 |
IC50 = 6.6 nM
|
|
|
|
CP0458237
|
N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-4-phenylbenzamide
Show/Hide
|
C28H27N3O
|
2
|
| 1 |
IC50 = 1.8 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0383012
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C26H29N3O2
|
2
|
| 1 |
IC50 = 1.8 nM
|
|
|
| 2 |
IC50 = 4.3 nM
|
|
|
|
CP0498456
|
(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(1H-1,2,3-triazol-1-yl)acetamide
Show/Hide
|
C26H29F2N5O2
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0428326
|
4-(4-fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C28H27FN2O
|
3
|
| 1 |
IC50 = 1.9 nM
|
|
|
| 2 |
IC50 = 7.9 nM
|
|
|
| 3 |
IC50 = 17 nM
|
|
|
|
CP0472693
|
4-(4-chlorophenyl)-N-[6-(piperidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C29H29ClN2O
|
2
|
| 1 |
IC50 = 1.9 nM
|
|
|
| 2 |
IC50 = 5.9 nM
|
|
|
|
CP0489108
|
N-[3-[1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0505656
|
6-(4-chlorophenyl)-3-[2-methyl-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C26H24ClN5OS
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0374867
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-phenylthieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C25H25N3O3S
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0538184
|
6-(4-chlorophenyl)-3-[2-(piperidin-1-ylmethyl)-1-benzothien-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H22ClN3OS2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0538454
|
6-(4-chlorophenyl)-3-[2-(1H-imidazol-1-ylmethyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H16ClN5OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0206375
|
N-[2-(1,4-diazepan-1-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H25F3N4O3
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 71 nM
|
|
|
|
CP0416008
|
N-[3-[1-(azepan-1-yl)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
Show/Hide
|
C29H35N3O2
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 3.4 nM
|
|
|
|
CP0421013
|
4-butoxy-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C26H31N3O2
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 2.6 nM
|
|
|
|
CP0474042
|
1-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-3-(3,4-difluorophenyl)-1-methyl-3-p-tolylurea
Show/Hide
|
C30H33F2N3O2
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0496585
|
1-(3,4-difluorophenyl)-3-(3-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)propyl)-3-methyl-1-p-tolylurea
Show/Hide
|
C31H35F2N3O
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0485584
|
4'-methylsulfanyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(S)-3-(3-phenyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide
Show/Hide
|
C33H40N4O2S
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0498842
|
4-(4-methoxyphenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C29H30N2O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0432922
|
4-(4-methylphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H27N3O
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0110894
|
3-((1R,4R,6R)-4-((5,6-dichloro-1H-benzo[d]imidazol-2-yl)(3-(4-methylpiperazin-1-yl)propyl)amino)bicyclo[4.1.0]heptan-1-yl)benzonitrile
Show/Hide
|
C29H34Cl2N6
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0378974
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-phenyl-urea
Show/Hide
|
C27H28N4O
|
2
|
| 1 |
IC50 = 2.2 nM
|
|
|
| 2 |
Ki = 2.2 nM
|
|
|
|
CP0442848
|
6-(4-chlorophenyl)-3-[2-(1-pyrrolidinylmethyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]thieno[3,2-d]pyrimidin-4 (3H)-one
Show/Hide
|
C25H23ClN4O2S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0200253
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H27F3N4O3
|
2
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0302898
|
N-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H25F3N4O3
|
2
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0206377
|
N-[2-[3-(dimethylamino)pyrrolidin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O3
|
2
|
| 1 |
IC50 = 2.4 nM
|
|
|
| 2 |
IC50 = 82 nM
|
|
|
|
CP0383008
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-(1-piperidin-1-ylethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H33N3O2
|
2
|
| 1 |
IC50 = 2.4 nM
|
|
|
| 2 |
IC50 = 3.2 nM
|
|
|
|
CP0553746
|
6-(4-chlorophenyl)-3-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]-methyl}-1-benzothien-5-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H20ClN3O2S2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0383014
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(2-methylpyrrolidin-1-yl)methyl]quinolin-7-yl]benzamide
Show/Hide
|
C27H31N3O2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0541286
|
6-(4-chlorophenyl)-3-[2-(dimethylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C21H16ClN5OS
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0408359
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-[4-(trifluoromethyl)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C26H24F3N3O3S
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0473771
|
1-(3,4-difluorophenyl)-1-[4-[(6-fluorospiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl]phenyl]ethanol
Show/Hide
|
C26H25F3N2O2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0046941
|
1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-butyl]-3-phenyl-urea
Show/Hide
|
C26H28N4O
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0374401
|
(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(2-oxopyrrolidin-1-yl)acetamide
Show/Hide
|
C28H33F2N3O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0518080
|
6-(4-chlorophenyl)-3-{6-[(dimethylamino)methyl]-7,8-dihydro-2-naphthalenyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H22ClN3OS
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0417492
|
4-(4-fluorophenyl)-N-[2-(pyrrolidin-1-ylmethyl)quinolin-6-yl]benzamide
Show/Hide
|
C27H24FN3O
|
2
|
| 1 |
IC50 = 2.7 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0426176
|
4-(4-chlorophenyl)-N-[6-[(4-methylpiperazin-1-yl)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C29H30ClN3O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0400414
|
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-propanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
Show/Hide
|
C28H35ClN2O2
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
IC50 = 5.2 nM
|
|
|
|
CP0461934
|
4-(4-fluorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C27H24FN3O
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
IC50 = 9.2 nM
|
|
|
|
CP0455395
|
(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)acetamide
Show/Hide
|
C26H29F2N5O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0046035
|
N-[3-[4-(4-chlorophenyl)phenyl]propyl]-4-(piperidin-1-ylmethyl)aniline
Show/Hide
|
C27H31ClN2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0247536
|
1-[[4-[3-(6-phenylmethoxypyridazin-3-yl)propylamino]phenyl]methyl]piperidin-4-ol
Show/Hide
|
C26H32N4O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0407716
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C20H18F3N3O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0536745
|
6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-5,6,7,8-tetrahydro-2-naphthalenyl]thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C28H28ClN3OS
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0529775
|
6-(4-chlorophenyl)-3-{2-[(4-methyl-1-piperazinyl)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H24ClN5OS
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0537890
|
6-(4-chlorophenyl)-3-(2-{[4-(4-fluorophenyl)-1-piperidinyl]-methyl}-6-quinolinyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C33H26ClFN4OS
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0473313
|
1-(3,5-Dichloro-phenyl)-3-[1-methyl-4-(4-pyridin-3-yl-phenyl)-piperidin-4-ylmethyl]-urea
Show/Hide
|
C25H26Cl2N4O
|
2
|
| 1 |
IC50 = 3.1 nM
|
|
|
| 2 |
Ki = 3.1 nM
|
|
|
|
CP0381725
|
6-(4-chlorophenyl)-3-[1-(4-ethoxyphenyl)-2-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C28H21ClN4O2S
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0501119
|
6-(4-chlorophenyl)-3-(2-pyrrolidin-1-yl-3H-benzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C23H18ClN5OS
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0408358
|
2-(4-chlorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-one
Show/Hide
|
C24H23ClN4O3S
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0428125
|
6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}thieno[3,2-d]pyrimidin-4 (3H)-one
Show/Hide
|
C23H21ClN4O2S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0442847
|
6-(4-chlorophenyl)-3-{(2R)-2-[(dimethylamino)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C23H20ClN3O3S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0370612
|
N-[2-[2-(diethylamino)ethylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H29F3N4O3
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0421008
|
5-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pentanamide
Show/Hide
|
C26H30FN3O
|
2
|
| 1 |
IC50 = 3.2 nM
|
|
|
| 2 |
IC50 = 3.9 nM
|
|
|
|
CP0408814
|
6-(4-chlorophenyl)-3-(2-{[(3R)-3-hydroxy-1-pyrrolidinyl]-methyl}-3,4-dihydro-2H-1,4-benzoxazin-6-yl)thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C25H23ClN4O3S
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0720135
|
rac-N-(2-(2,5-dimethylpiperazin-1-yl)-4-methylquinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide
Show/Hide
|
C25H27F3N4O3
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0421009
|
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(1S)-1-pyrrolidin-1-ylethyl]quinolin-7-yl]benzamide
Show/Hide
|
C27H31N3O2
|
2
|
| 1 |
IC50 = 3.4 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0428065
|
6-(4-chlorophenyl)-3-[2-(hydroxymethyl)-6-quinolinyl]thieno-[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C22H14ClN3O2S
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0529712
|
6-(4-chlorophenyl)-3-{2-[(4-methyl-1-piperazinyl)methyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C26H26ClN5O2S
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0502775
|
1'-(4-(3,4-difluorophenoxy)benzyl)-6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]
Show/Hide
|
C24H21F3N2O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0549158
|
4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile
Show/Hide
|
C31H26F4N4
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0034946
|
N-[4-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O3
|
2
|
| 1 |
IC50 = 3.7 nM
|
|
|
| 2 |
IC50 = 244 nM
|
|
|
|
CP0034947
|
(S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide
Show/Hide
|
C24H25F3N4O3
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0458176
|
4-(4-methoxyphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H27N3O2
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0462346
|
6-(4-chlorophenyl)-3-{2-[(4-phenyl-1-piperazinyl)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C32H26ClN5OS
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0424497
|
1-(4-{2-[Benzyl(methyl)amino]ethoxy}phenyl)-4-(benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C28H28N2O3
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0499067
|
4-(cyclopropylmethoxy)-N-[3-[1-(2-hydroxyethylamino)ethyl]-8-methylquinolin-7-yl]benzamide
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0407714
|
N-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C18H16F3N3O3
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1
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| 1 |
IC50 = 3.8 nM
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CP0475339
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4-[4-(4-chlorophenyl)piperidin-1-yl]-1-[3-(cyclopropanecarbonyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]butan-1-one
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C29H35ClN2O2
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2
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| 1 |
IC50 = 3.9 nM
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| 2 |
IC50 = 5.4 nM
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CP0394817
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6-(4-chlorophenyl)-3-[2-(methylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C20H14ClN5OS
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1
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| 1 |
IC50 = 3.981 nM
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CP0095681
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[1-[[4-[3-[6-(4-chlorophenyl)pyridazin-3-yl]propoxy]phenyl]methyl]piperidin-4-yl]methanol
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C26H30ClN3O2
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1
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| 1 |
IC50 = 4 nM
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CP0188203
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N-[3-[6-(4-chlorophenyl)pyridazin-3-yl]propyl]-4-(piperidin-1-ylmethyl)aniline
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C25H29ClN4
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1
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| 1 |
IC50 = 4 nM
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CP0172315
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(R)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide
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C24H25F3N4O3
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2
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| 1 |
IC50 = 4.1 nM
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| 2 |
IC50 = 100 nM
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CP0423540
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6-(4-chlorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pyridine-3-carboxamide
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C26H23ClN4O
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2
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| 1 |
IC50 = 4.1 nM
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| 2 |
IC50 = 14 nM
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CP0524645
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4-[(3-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one
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C24H25ClN2O3
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1
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| 1 |
IC50 = 4.2 nM
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CP0417411
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5-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-5-oxopentanamide
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C26H28FN3O2
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1
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| 1 |
IC50 = 4.3 nM
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CP0478492
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4-(Benzyloxy)-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-pyridin-2(1H)-one
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C25H28N2O3
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2
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| 1 |
IC50 = 4.4 nM
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| 2 |
IC50 = 19 nM
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CP0416006
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4-(2-methylpropoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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C26H31N3O2
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1
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| 1 |
IC50 = 4.4 nM
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CP0475139
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4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-ethylsulfonyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
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C27H35ClN2O3S
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2
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| 1 |
IC50 = 4.5 nM
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| 2 |
IC50 = 5.3 nM
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CP0491237
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3,4-difluoro-N-(4-((6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl)phenyl)aniline
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C24H22F3N3O
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1
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| 1 |
IC50 = 4.6 nM
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CP0459932
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4-(4-chlorophenyl)-N-[6-[[methyl(propanoyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27ClN2O2
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1
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| 1 |
IC50 = 4.6 nM
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CP0178770
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N-[2-[[3-(dimethylamino)-2,2-dimethylpropyl]amino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C26H31F3N4O3
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2
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| 1 |
IC50 = 4.7 nM
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| 2 |
IC50 = 192 nM
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CP0452187
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1-(3-butanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
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C29H37ClN2O2
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2
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| 1 |
IC50 = 4.7 nM
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| 2 |
IC50 = 7.4 nM
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CP0562102
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4'-[6-cyclopropylmethyl-1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
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C32H28F4N4
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1
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| 1 |
IC50 = 4.8 nM
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CP0408818
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6-(4-chlorophenyl)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
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C26H21ClN4O2S
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1
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| 1 |
IC50 = 4.9 nM
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CP0562519
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4-[(1S,4R,6R)-4-[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)-[3-(4-methylpiperazin-1-yl)propyl]amino]-1-bicyclo[4.1.0]heptanyl]benzonitrile
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C29H34ClFN6
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1
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| 1 |
IC50 = 4.9 nM
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CP0509825
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benzyl N-[2-[[2,2-diphenyl-5-(4-phenylpiperidin-1-yl)pentyl]amino]-2-oxoethyl]carbamate
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C38H43N3O3
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1
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| 1 |
IC50 = 5 nM
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CP0505653
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6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]-N-[2-(1-pyrrolidinyl)ethyl]-2-naphthalenecarboxamide
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C29H25ClN4O2S
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1
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| 1 |
IC50 = 5 nM
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CP0439707
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4'-[1-cyclohexylmethyl-3-(3-methoxy-phenyl)-2,4-dioxo-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl]-biphenyl-3-carbonitrile
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C35H38N4O3
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1
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| 1 |
IC50 = 5 nM
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CP0392518
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N-[3-[1-[3-[4-(4-fluorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
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C30H31FN4O2
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1
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| 1 |
IC50 = 5 nM
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CP0408316
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-1-propylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C24H22ClN5OS
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1
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| 1 |
IC50 = 5.012 nM
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CP0428196
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-3-propylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C24H22ClN5OS
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1
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| 1 |
IC50 = 5.012 nM
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CP0485893
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6-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)-2-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C27H19ClN4O2S
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1
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| 1 |
IC50 = 5.012 nM
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CP0496010
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6-(4-chlorophenyl)-3-[2-[methyl(2-pyrrolidin-1-ylethyl)amino]-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C26H25ClN6OS
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1
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| 1 |
IC50 = 5.012 nM
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CP0496903
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6-(4-chlorophenyl)-3-(2-piperidin-1-yl-3H-benzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C24H20ClN5OS
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1
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| 1 |
IC50 = 5.012 nM
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CP0500676
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6-(4-chlorophenyl)-3-[1-(3-methoxypropyl)-2-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C24H21ClN4O2S
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1
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| 1 |
IC50 = 5.012 nM
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CP0501120
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6-(4-chlorophenyl)-3-[1-[4-(dimethylamino)phenyl]-2-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C28H22ClN5OS
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1
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| 1 |
IC50 = 5.012 nM
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CP0407236
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3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(4-nitrophenyl)thieno[3,2-d]pyrimidin-4-one
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C25H24N4O5S
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1
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| 1 |
IC50 = 5.012 nM
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CP0522883
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6-(2-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C25H24ClN3O3S
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1
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| 1 |
IC50 = 5.012 nM
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CP0404343
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4-(Benzyloxy)-1-{4-[2-(diisopropylamino)ethoxy]-phenyl}pyridin-2(1H)-one
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C26H32N2O3
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2
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| 1 |
IC50 = 5.1 nM
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| 2 |
IC50 = 22 nM
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CP0198315
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1-(3'-Cyano-biphenyl-4-yl)-3-(3-fluoro-4-trifluoromethyl-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea
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C27H24F4N4O
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1
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| 1 |
IC50 = 5.2 nM
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CP0496853
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N-[2-(diethylamino)ethyl]-4-[[4-(trifluoromethyl)phenyl]carbamoylamino]benzamide
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C21H25F3N4O2
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2
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| 1 |
IC50 = 5.3 nM
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| 2 |
IC50 = 170 nM
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CP0459770
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6-(4-chlorophenyl)-3-(2-{[(3S)-3-hydroxy-1-pyrrolidinyl]-methyl}-3,4-dihydro-2H-1,4-benzoxazin-6-yl)thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
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C25H23ClN4O3S
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1
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| 1 |
IC50 = 5.3 nM
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CP0172433
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N-[2-[2-(dimethylamino)ethylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
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C23H25F3N4O3
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1
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| 1 |
IC50 = 5.3 nM
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CP0481426
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N-[3-[(1S)-1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
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C27H32N4O3
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2
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| 1 |
IC50 = 5.3 nM
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| 2 |
IC50 = 6.9 nM
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CP0160875
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1-[2-[4-(3-cyanophenyl)phenyl]-4-piperidin-1-ylbutyl]-3-(3,5-dichlorophenyl)urea
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C29H30Cl2N4O
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1
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| 1 |
IC50 = 5.4 nM
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CP0413189
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4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide
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C26H27FN2O
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4
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| 1 |
IC50 = 5.5 nM
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| 2 |
IC50 = 14 nM
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| 3 |
IC50 = 43 nM
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| 4 |
Ki = 38 nM
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CP0903416
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4'-Chloro-N-[6-(methylamino)methyl]-7,8-dihydro-2-naphthalenyl][1,1'-biphenyl]-4-carboxamide 2,2,2-trifluoroacetate
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C27H24ClF3N2O3
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1
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| 1 |
IC50 = 5.5 nM
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CP0410727
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4-(cyclopropylmethoxy)-N-[3-[1-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]-8-methylquinolin-7-yl]benzamide
Show/Hide
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C27H31N3O3
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1
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| 1 |
IC50 = 5.5 nM
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CP0538261
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1-(3,5-Dichloro-phenyl)-3-[4-(3'-formyl-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-urea
Show/Hide
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C27H27Cl2N3O2
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2
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| 1 |
IC50 = 5.5 nM
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| 2 |
Ki = 5.5 nM
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CP0518098
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6-(4-chlorophenyl)-3-(2-{[4-(1-pyrrolidinyl)-1-piperidinyl]-methyl}-6-quinolinyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C31H30ClN5OS
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1
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| 1 |
IC50 = 5.6 nM
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CP0379612
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4-(4-fluorobenzyloxy)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one
Show/Hide
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C24H25FN2O3
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2
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| 1 |
IC50 = 5.6 nM
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| 2 |
IC50 = 23 nM
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CP0400412
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1-(2-acetyl-3,4-dihydro-1H-isoquinolin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
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C26H31ClN2O2
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2
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| 1 |
IC50 = 5.6 nM
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| 2 |
IC50 = 6.2 nM
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CP0442433
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6-(4-chlorophenyl)-3-{2-[(4-phenylpiperidin-1-yl)methyl]-1-benzothien-5-yl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C32H26ClN3OS2
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1
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| 1 |
IC50 = 5.7 nM
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CP0225373
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N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-4-phenylbenzamide
Show/Hide
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C28H30N4O
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2
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| 1 |
IC50 = 5.7 nM
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| 2 |
IC50 = 25 nM
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CP0501321
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4-(Benzyloxy)-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-pyridin-2(1H)-one
Show/Hide
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C24H26N2O3
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2
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| 1 |
IC50 = 5.8 nM
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| 2 |
IC50 = 27 nM
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CP0379749
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4-[(3-Fluorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one
Show/Hide
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C24H25FN2O3
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2
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| 1 |
IC50 = 5.9 nM
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| 2 |
IC50 = 22 nM
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CP0441257
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N-[3-[1-[3-[4-(4-chloro-3-fluorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H30ClFN4O2
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1
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| 1 |
IC50 = 6 nM
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CP0066833
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1-[[4-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propylamino]phenyl]methyl]piperidin-3-ol
Show/Hide
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C26H32N4O2
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1
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| 1 |
IC50 = 6 nM
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CP0537915
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6-(4-chlorophenyl)-3-[2-({4-[4-(trifluoromethyl)phenyl]-1-piperidinyl}methyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C34H26ClF3N4OS
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1
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| 1 |
IC50 = 6.1 nM
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CP0442849
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6-(4-chlorophenyl)-3-{2-[(4-ethyl-1-piperazinyl)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C28H26ClN5OS
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1
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| 1 |
IC50 = 6.2 nM
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CP0496201
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(3,4-difluorophenyl)-[4-[(6-fluorospiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)methyl]phenyl]methanol
Show/Hide
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C25H23F3N2O2
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1
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| 1 |
IC50 = 6.3 nM
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CP0376172
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6-(4-chlorophenyl)-3-[2-(2-pyrrolidin-1-ylethylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C25H23ClN6OS
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1
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| 1 |
IC50 = 6.31 nM
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CP0485891
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6-(4-chlorophenyl)-3-[2-methyl-1-(2-morpholin-4-ylethyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C26H24ClN5O2S
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1
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| 1 |
IC50 = 6.31 nM
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CP0485892
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6-(4-chlorophenyl)-3-(1-cyclohexyl-2-methylbenzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C26H23ClN4OS
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1
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| 1 |
IC50 = 6.31 nM
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CP0497177
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-1-methylbenzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C22H18ClN5OS
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1
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| 1 |
IC50 = 6.31 nM
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CP0541282
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6-(4-chlorophenyl)-3-(3-methyl-2-pyrrolidin-1-ylbenzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C24H20ClN5OS
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1
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| 1 |
IC50 = 6.31 nM
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CP0449435
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7-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]quinazolin-4-one
Show/Hide
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C27H26ClN3O3
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1
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| 1 |
IC50 = 6.31 nM
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CP0485852
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6-(3-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C25H24ClN3O3S
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1
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| 1 |
IC50 = 6.31 nM
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CP0472692
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4-phenyl-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
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C28H28N2O
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2
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| 1 |
IC50 = 6.4 nM
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| 2 |
IC50 = 17 nM
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CP0378845
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4-(Benzyloxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}-pyridin-2(1H)-one
Show/Hide
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C24H28N2O3
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2
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| 1 |
IC50 = 6.6 nM
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| 2 |
IC50 = 24 nM
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CP0476216
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
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C27H33ClN2O2
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2
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| 1 |
IC50 = 6.6 nM
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| 2 |
IC50 = 11 nM
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CP0462673
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4-(4-chlorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide
Show/Hide
|
C26H29ClN4O
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1
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| 1 |
IC50 = 6.6 nM
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CP0425734
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1-{4-[2-(Pyrrolidin-1-yl)ethoxy]phenyl}-4-{[4-(trifluoromethyl)benzyl]oxy}pyridin-2(1H)-one
Show/Hide
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C25H25F3N2O3
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2
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| 1 |
IC50 = 6.7 nM
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| 2 |
IC50 = 49 nM
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CP0387991
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4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-methylsulfonyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
Show/Hide
|
C26H33ClN2O3S
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2
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| 1 |
IC50 = 6.7 nM
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| 2 |
IC50 = 9.2 nM
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CP0102519
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(Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methyl)pyridin-3-yl)methyl)-5-methyl-3H-spiro[furo[3,4-c]pyridine-1,4'-piperidin]-6(5H)-one
Show/Hide
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C27H28F2N4O3
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2
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| 1 |
IC50 = 6.8 nM
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| 2 |
IC50 = 25 nM
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CP0498591
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4-(Benzyloxy)-1-(4-{[2-(diethylamino)ethyl]amino}-phenyl)pyridin-2(1H)-one
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C24H29N3O2
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1
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| 1 |
IC50 = 6.8 nM
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CP0494230
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N-[6-[[acetyl(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]-4-(4-chlorophenyl)benzamide
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C27H25ClN2O2
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1
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| 1 |
IC50 = 6.8 nM
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CP0505227
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2-(4-chlorophenyl)-5-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)furo[3,2-c]pyridin-4-one
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C24H18ClN3O2
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2
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| 1 |
IC50 = 6.8 nM
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| 2 |
IC50 = 42 nM
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CP0537724
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3-[(1S,4R,6R)-4-[(5,6-difluoro-1H-benzimidazol-2-yl)-[(4-methylsulfonylpiperazin-1-yl)methyl]amino]-1-bicyclo[4.1.0]heptanyl]benzonitrile
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C27H30F2N6O2S
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1
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| 1 |
IC50 = 6.8 nM
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CP0527052
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(R)-6-(4-chlorophenyl)-3-(2-(cyclopentylmethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C25H22ClN3O3S
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1
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| 1 |
IC50 = 7 nM
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CP0380603
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4-[(4-Methoxybenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)-ethoxy]phenyl}pyridin-2(1H)-one
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C25H28N2O4
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 11 nM
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CP0524695
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N-[3-[1-[3-[4-(2,4-difluorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
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C30H30F2N4O2
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1
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| 1 |
IC50 = 7 nM
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CP0059284
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N-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propyl]-4-(piperidin-1-ylmethyl)aniline
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C26H32N4O
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1
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| 1 |
IC50 = 7 nM
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CP0303039
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N-[2-[2-[di(propan-2-yl)amino]ethylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C27H33F3N4O3
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1
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| 1 |
IC50 = 7.1 nM
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CP0400415
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1-[7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-1,2,4,5-tetrahydro-3-benzazepin-3-yl]pentan-1-one
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C30H39ClN2O2
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2
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| 1 |
IC50 = 7.2 nM
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| 2 |
IC50 = 11 nM
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CP0494590
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4-(4-chlorophenyl)-N-[6-[[methyl(2-phenylethyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
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C33H31ClN2O
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2
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| 1 |
IC50 = 7.4 nM
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| 2 |
IC50 = 33 nM
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CP0526929
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6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}thieno[3,2-d]pyrimidin-4-(3H)-one
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C23H20ClN3O3S
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1
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| 1 |
IC50 = 7.7 nM
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CP0413188
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4-(Naphthalen-2-ylmethoxy)-1-{4-[2-(pyrrolidin-1-yl)-ethoxy]phenyl}pyridin-2(1H)-one
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C28H28N2O3
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2
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| 1 |
IC50 = 7.7 nM
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| 2 |
IC50 = 175 nM
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CP0407728
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4-[(5-chlorothiophen-3-yl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
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C21H18ClN3O2S
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2
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| 1 |
IC50 = 7.7 nM
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| 2 |
IC50 = 19 nM
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CP0526882
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4-(cyclopropylmethoxy)-N-[8-methyl-3-(2-pyrrolidin-1-ylpropan-2-yl)quinolin-7-yl]benzamide
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C28H33N3O2
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1
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| 1 |
IC50 = 7.8 nM
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CP0464330
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6-(4-chlorophenyl)-3-[2-(propan-2-ylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C22H18ClN5OS
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1
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| 1 |
IC50 = 7.943 nM
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CP0499597
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6-(4-chlorophenyl)-3-[2-methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
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C29H23ClN4O2S
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1
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| 1 |
IC50 = 7.943 nM
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CP0496854
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2-Methoxy-4-[3-(3-phenylamino-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
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C29H35N5O3
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2
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| 1 |
IC50 = 8.1 nM
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| 2 |
IC50 = 20 nM
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CP0392050
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7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-N-ethyl-1,2,4,5-tetrahydro-3-benzazepine-3-carboxamide
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C28H36ClN3O2
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1
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| 1 |
IC50 = 8.1 nM
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CP0043469
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ATC0175
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C23H25F2N5O
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1
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| 1 |
IC50 = 8.28 nM
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CP0396718
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N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-methylphenyl)benzamide
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C27H30N2O
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2
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| 1 |
IC50 = 8.4 nM
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| 2 |
IC50 = 18 nM
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CP0457411
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4-(4-chlorophenyl)-N-[6-(morpholin-4-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27ClN2O2
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2
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| 1 |
IC50 = 8.4 nM
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| 2 |
IC50 = 29 nM
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CP0502031
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6-(4-chlorophenyl)-3-[2-(4-morpholinylmethyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
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C25H23ClN4O3S
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1
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| 1 |
IC50 = 8.5 nM
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CP0398787
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4-[(2-Fluorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one
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C24H25FN2O3
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2
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| 1 |
IC50 = 8.7 nM
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| 2 |
IC50 = 30 nM
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CP0258554
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N-[1-[[4-[3-(6-phenoxypyridazin-3-yl)propylamino]phenyl]methyl]piperidin-4-yl]acetamide
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C27H33N5O2
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1
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| 1 |
IC50 = 9 nM
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CP0451708
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3-(2-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-1-benzofuran-5-yl)-6-(4-methylphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
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C27H24ClN3O3S
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1
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| 1 |
IC50 = 9.5 nM
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CP0478495
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4-(Benzyloxy)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-pyridin-2(1H)-one
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C22H24N2O3
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2
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| 1 |
IC50 = 9.5 nM
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| 2 |
IC50 = 18 nM
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CP0431195
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1-(3,4-difluorophenyl)-3-(3-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)propyl)-1-p-tolylurea
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C30H33F2N3O
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1
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| 1 |
IC50 = 9.6 nM
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CP0442431
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6-(4-chlorophenyl)-3-{2-[(4-methylpiperazin-1-yl)methyl]-1-benzothien-5-yl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C26H23ClN4OS2
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1
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| 1 |
IC50 = 9.7 nM
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CP0514711
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(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(1H-tetrazol-1-yl)acetamide
Show/Hide
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C25H28F2N6O2
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1
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| 1 |
IC50 = 9.9 nM
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CP0425459
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4-(4-chlorophenyl)-N-[6-(diethylaminomethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H29ClN2O
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1
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| 1 |
IC50 = 9.9 nM
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CP0391852
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2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide
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C23H24Cl2N4O2
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1
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| 1 |
IC50 = 10 nM
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CP0172420
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4'-trifluoromethyl-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-amide
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C29H29F3N4O
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 474 nM
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CP0503386
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-1-(4-methoxyphenyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C28H22ClN5O2S
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1
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| 1 |
IC50 = 10 nM
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CP0505654
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-1-(2-hydroxyethyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C23H20ClN5O2S
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1
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| 1 |
IC50 = 10 nM
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CP0066831
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N-[1-[[4-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propylamino]phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C28H35N5O2
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1
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| 1 |
IC50 = 10 nM
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CP0066845
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N-[1-[[4-[3-(6-phenoxypyridazin-3-yl)propoxy]phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C27H32N4O3
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1
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| 1 |
IC50 = 10 nM
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CP0188201
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3-[4-(4-chlorophenyl)phenyl]-N-[4-(piperidin-1-ylmethyl)phenyl]prop-2-ynamide
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C27H25ClN2O
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1
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| 1 |
IC50 = 10 nM
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CP0537726
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4'-[6-benzyl-1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
Show/Hide
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C35H28F4N4
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1
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| 1 |
IC50 = 10.3 nM
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CP0457412
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4-(4-chlorophenyl)-N-[6-[(N-methylanilino)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
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C31H27ClN2O
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 47 nM
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CP0536503
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[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
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C25H27ClN4O3
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 20 nM
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CP0659430
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3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid [(R)-1-(4,4-dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-amide
Show/Hide
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C31H41F3N4O2S
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1
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| 1 |
IC50 = 12 nM
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CP0380413
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4-[(2-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one
Show/Hide
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C24H25ClN2O3
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1
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| 1 |
IC50 = 12 nM
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CP0478493
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4-(Benzyloxy)-1-{4-[(1-methylpyrrolidin-2-yl)methoxy]-phenyl}pyridin-2(1H)-one
Show/Hide
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C24H26N2O3
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2
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| 1 |
IC50 = 12 nM
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| 2 |
IC50 = 23 nM
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CP0387992
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methyl 7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylate
Show/Hide
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C27H33ClN2O3
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1
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| 1 |
IC50 = 12 nM
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CP0390332
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N-[3-[1-[3-[4-(3,4-dichlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H30Cl2N4O2
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1
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| 1 |
IC50 = 12 nM
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CP0526880
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4-(cyclopropylmethoxy)-N-[8-methyl-3-[1-(4-methylpiperazin-1-yl)ethyl]quinolin-7-yl]benzamide
Show/Hide
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C28H34N4O2
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1
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| 1 |
IC50 = 12 nM
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CP0452306
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4-[(4-bromophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
Show/Hide
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C23H20BrN3O2
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1
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| 1 |
IC50 = 12 nM
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CP0421356
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-3-(2-hydroxyethyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C23H20ClN5O2S
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1
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| 1 |
IC50 = 12.59 nM
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CP0496009
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6-(4-chlorophenyl)-3-[2-(dimethylamino)-1-[(4-methoxyphenyl)methyl]benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C29H24ClN5O2S
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1
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| 1 |
IC50 = 12.59 nM
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CP0503376
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6-(4-aminophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C25H26N4O3S
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1
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| 1 |
IC50 = 12.59 nM
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CP0206376
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N-[2-[(1-benzylpiperidin-4-yl)amino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
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C31H31F3N4O3
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2
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| 1 |
IC50 = 13 nM
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| 2 |
IC50 = 91 nM
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CP0417493
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4-phenyl-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
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C27H25N3O
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1
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| 1 |
IC50 = 13 nM
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CP0059206
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[1-[[4-[3-(6-phenoxypyridazin-3-yl)propoxy]phenyl]methyl]piperidin-4-yl]methanol
Show/Hide
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C26H31N3O3
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1
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| 1 |
IC50 = 13 nM
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CP0281039
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1-[[4-[3-[6-(4-chlorophenyl)pyridazin-3-yl]propoxy]phenyl]methyl]piperidin-4-ol
Show/Hide
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C25H28ClN3O2
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1
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| 1 |
IC50 = 13 nM
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CP0290245
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N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]propanamide
Show/Hide
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C25H29F3N4O2
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2
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| 1 |
IC50 = 14 nM
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| 2 |
IC50 = 724 nM
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CP0441253
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N-[3-[1-[3-[4-(4-chlorophenyl)-7-fluoro-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H30ClFN4O2
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1
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| 1 |
IC50 = 14 nM
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CP0441368
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N-[3-[1-[3-[7-chloro-4-(4-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H30Cl2N4O2
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1
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| 1 |
IC50 = 14 nM
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CP0490517
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4-[(5-chlorothiophen-3-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
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C21H18ClN3O2S
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1
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| 1 |
IC50 = 14 nM
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CP0524694
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N-[3-[1-[3-[4-(4-chlorophenyl)-7-methoxy-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C31H33ClN4O3
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1
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| 1 |
IC50 = 15 nM
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CP0348653
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N-[1-[[4-[3-[6-(4-fluorophenyl)pyridazin-3-yl]propoxy]phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C27H31FN4O2
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1
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| 1 |
IC50 = 15 nM
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CP0545406
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(3R)-1-[[4-[3-[6-(4-chlorophenyl)pyridazin-3-yl]propoxy]phenyl]methyl]piperidin-3-ol
Show/Hide
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C25H28ClN3O2
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1
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| 1 |
IC50 = 15 nM
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CP0551739
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[5-[4-(difluoromethoxy)phenyl]-1,3,4-oxadiazol-2-yl]-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C26H28F2N4O4
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1
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| 1 |
IC50 = 15 nM
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CP0449454
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6-(4-chlorophenyl)-3-(2-morpholin-4-yl-3H-benzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C23H18ClN5O2S
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1
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| 1 |
IC50 = 15.85 nM
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CP0541285
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6-(4-chlorophenyl)-3-[2-(cyclopropylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C22H16ClN5OS
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1
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| 1 |
IC50 = 15.85 nM
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CP0034944
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(E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
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C25H27F3N4O2
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 144 nM
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CP0425662
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4-(Benzyloxy)-1-(4-{[2-(diethylamino)ethyl](methyl)-amino}phenyl)pyridin-2(1H)-one
Show/Hide
|
C25H31N3O2
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1
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| 1 |
IC50 = 16 nM
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CP0129332
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(E)-3-[4-(4-chlorophenyl)phenyl]-N-[4-(piperidin-1-ylmethyl)phenyl]prop-2-enamide
Show/Hide
|
C27H27ClN2O
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1
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| 1 |
IC50 = 16 nM
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CP0305554
|
US8685958, 4
Show/Hide
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C26H28N4O5
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1
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| 1 |
IC50 = 16 nM
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CP0261349
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[3-[3-methoxy-4-(morpholin-4-ylmethyl)phenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C25H28N4O6
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2
|
| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 27 nM
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CP0376292
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1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
Show/Hide
|
C22H18F3N3O2S
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 18 nM
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CP0445539
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(E)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-(4-methylphenyl)prop-2-enamide
Show/Hide
|
C25H30N4O
|
2
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| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 478 nM
|
|
|
|
CP0457410
|
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-methoxyphenyl)benzamide
Show/Hide
|
C27H30N2O2
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0472705
|
4-(2-chlorophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
Show/Hide
|
C26H27ClN2O
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 65 nM
|
|
|
|
CP0192972
|
N-[3-[4-(4-chlorophenyl)phenyl]propyl]-N-methyl-4-(piperidin-1-ylmethyl)aniline
Show/Hide
|
C28H33ClN2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0511825
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
Show/Hide
|
C22H18F3N3O2S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0409752
|
4-[(4-chlorothiophen-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C21H18ClN3O2S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0283770
|
(R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrrolidin-3-yl)benzamide
Show/Hide
|
C24H26N2O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0378846
|
4-(Benzyloxy)-1-{4-[(1-methylpiperidin-2-yl)methoxy]-phenyl}pyridin-2(1H)-one
Show/Hide
|
C25H28N2O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0478494
|
4-(Benzyloxy)-1-{4-[(1-methylpyrrolidin-3-yl)oxy]-phenyl}pyridin-2(1H)-one
Show/Hide
|
C23H24N2O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0489268
|
6-(4-methylphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pyridine-3-carboxamide
Show/Hide
|
C27H26N4O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0509248
|
1-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-3-(3,4-difluorophenyl)-1-methyl-3-phenylurea
Show/Hide
|
C29H31F2N3O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0536732
|
6-(4-chlorophenyl)-3-[2-({4-[2-(4-morpholinyl)ethyl]-1-piperazinyl}methyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C32H33ClN6O2S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0396715
|
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-ethylphenyl)benzamide
Show/Hide
|
C28H32N2O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 43 nM
|
|
|
|
CP0387989
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-methylphenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C28H36N2O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0400413
|
1-(5-acetyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C24H29ClN2O2S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0261350
|
[3-[4-[(3-methoxyazetidin-1-yl)methyl]phenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C24H26N4O5
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0380259
|
4-[(5-chlorothiophen-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C21H18ClN3O2S
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
|
CP0497178
|
6-(4-chlorophenyl)-3-[2-methyl-1-(4-methylphenyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C27H19ClN4OS
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0562082
|
4-[3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-oxothieno[3,2-d]pyrimidin-6-yl]benzonitrile
Show/Hide
|
C26H24N4O3S
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0425150
|
2-Methoxy-4-[3-(3-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
Show/Hide
|
C29H34N4O4
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0430038
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethyl)phenyl]carbamoylamino]benzamide
Show/Hide
|
C22H27F3N4O3
|
3
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
| 3 |
IC50 = 170 nM
|
|
|
|
CP0276445
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(6-fluoropyridin-3-yl)benzamide
Show/Hide
|
C23H19FN4O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0427933
|
1-[4-(4-chlorophenyl)piperidin-1-yl]-4-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)butane-1,4-dione
Show/Hide
|
C25H29ClN2O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0476203
|
4-(4-phenylpiperidin-1-yl)-1-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)butan-1-one
Show/Hide
|
C25H32N2O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0437561
|
N-[3-[1-[3-[4-(4-chlorophenyl)-7-oxothieno[2,3-d]pyridazin-6-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C28H29ClN4O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0457214
|
N-[3-[1-[3-[6-chloro-4-(4-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H30Cl2N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0498309
|
N-[3-[1-[3-[4-(4-chlorophenyl)-6-methyl-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H33ClN4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0500484
|
N-[3-[1-[3-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31ClN4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0523515
|
N-[3-[1-[3-[6,7-dichloro-4-(4-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H29Cl3N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0110656
|
1-[6-[(3R)-3-aminopyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Show/Hide
|
C21H22N4O2
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0429041
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-phenylsulfanyl-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H27N3O3S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0116267
|
1-[[4-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propylamino]phenyl]methyl]piperidin-4-ol
Show/Hide
|
C26H32N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0178183
|
N-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propyl]-4-(morpholin-4-ylmethyl)aniline
Show/Hide
|
C25H30N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0067357
|
[3-[4-(5-oxa-2-azaspiro[3.4]octan-2-ylmethyl)phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C25H26N4O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0309679
|
US8685958, 7
Show/Hide
|
C25H26N4O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0356962
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(6-oxa-2-azaspiro[3.4]octan-2-ylmethyl)phenoxy]azetidin-1-yl]methanone
Show/Hide
|
C26H28N4O5
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0473311
|
4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(thiophene-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile
Show/Hide
|
C32H22F4N4OS
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0453231
|
N-[3-[6-(4-fluorophenyl)pyridazin-3-yl]propyl]-4-(piperidin-1-ylmethyl)aniline
Show/Hide
|
C25H29FN4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0259095
|
[3-[4-[(dimethylamino)methyl]-2-methylphenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0254957
|
3-((1R,4R,6R)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)(3-(4-methylpiperazin-1-yl)propyl)amino)bicyclo[4.1.0]heptan-1-yl)benzonitrile
Show/Hide
|
C29H34F2N6
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0563657
|
N-[1-[[4-[3-(6-benzylpyridazin-3-yl)propoxy]phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
|
C28H34N4O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0066592
|
[3-[4-[(3-hydroxy-3-methylpyrrolidin-1-yl)methyl]phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C24H26N4O4
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0133644
|
[3-[4-[(dimethylamino)methyl]-3-fluorophenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C22H23FN4O4
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0077720
|
4-(4-chlorophenyl)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)cyclohexanecarboxamide
Show/Hide
|
C28H35ClN4O
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
IC50 = 393 nM
|
|
|
|
CP0550722
|
4-(4-methylphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide
Show/Hide
|
C27H32N4O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0407713
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0197911
|
[3-[4-[(3-hydroxy-3-methylpyrrolidin-1-yl)methyl]phenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C25H28N4O5
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0270983
|
[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C24H24N4O4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0356964
|
[3-[4-[(dimethylamino)methyl]-3-methylphenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0518090
|
6-(4-chlorophenyl)-3-(2-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-1-methyl-1H-indol-5-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H22ClN3O3S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0425663
|
4-(Benzyloxy)-1-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-pyridin-2(1H)-one
Show/Hide
|
C24H26N2O4
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0095679
|
1-[[4-[3-(6-phenoxypyridazin-3-yl)propylamino]phenyl]methyl]piperidin-4-ol
Show/Hide
|
C25H30N4O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0443346
|
4-[(5-chloropyridin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0045217
|
(S)-N-(6-(((2-(dimethylamino)-2-oxoethyl)(methyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4'-fluoro-N-methylbiphenyl-4-carboxamide
Show/Hide
|
C30H34FN3O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0180184
|
1-[4-Cyclopentylamino-2-(4-pyridin-3-yl-phenyl)-butyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C27H30Cl2N4O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0495981
|
6-(4-chlorophenyl)-3-{(2S)-2-[(dimethylamino)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}thieno[3,2-d]pyrimidin-4-(3H)-one
Show/Hide
|
C23H20ClN3O3S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0460837
|
6-(4-fluorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pyridine-3-carboxamide
Show/Hide
|
C26H23FN4O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0414890
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(thiophen-3-ylmethoxy)pyridin-2-one
Show/Hide
|
C21H19N3O2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0305513
|
[4-[4-[(4-hydroxy-3,3-dimethylpyrrolidin-1-yl)methyl]phenoxy]piperidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C28H34N4O5
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
|
CP0146532
|
[3-[3-fluoro-4-[(4-methylpiperazin-1-yl)methyl]phenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C25H28FN5O4
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0425430
|
6-(4-chlorophenyl)-3-(2-methyl-3H-benzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C20H13ClN4OS
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0449453
|
6-(4-chlorophenyl)-3-(1-methyl-2-pyrrolidin-1-ylbenzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C24H20ClN5OS
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0453064
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-thiophen-3-ylthieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C23H23N3O3S2
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0542430
|
6-(3-iodophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C25H24IN3O3S
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0207080
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-pyridin-2-ylbenzamide
Show/Hide
|
C23H20N4O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0509932
|
N-[3-[1-[3-[4-(3-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31ClN4O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0423538
|
6-(4-methoxyphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pyridine-3-carboxamide
Show/Hide
|
C27H26N4O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0401609
|
[4-[4-[(3-hydroxypyrrolidin-1-yl)methyl]phenoxy]piperidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C26H30N4O5
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
|
CP0467481
|
N-[3-[1-[3-[1-oxo-4-(2,3,5-trifluorophenyl)phthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H29F3N4O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0527573
|
N-[3-[1-[3-[4-(2,4-dichlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H30Cl2N4O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0274543
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]methanone
Show/Hide
|
C25H26N4O5
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0095788
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0401611
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-(thiophen-3-ylmethoxy)pyridin-2-one
Show/Hide
|
C21H19N3O2S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0408619
|
6-(4-chlorophenyl)-3-{2-[(4-phenylpiperazin-1-yl)methyl]-1-benzothien-5-yl}thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C31H25ClN4OS2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0207084
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)pyrimidine-2-carboxamide
Show/Hide
|
C22H18FN5O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0214543
|
[3-[4-[(dimethylamino)methyl]phenoxy]azetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C22H24N4O4
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0469223
|
2-(4-Chloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-acetamide
Show/Hide
|
C24H27ClN4O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0476218
|
1-[4-(4-chlorophenyl)piperidin-1-yl]-4-(3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butane-1,4-dione
Show/Hide
|
C26H31ClN2O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0424079
|
N-[3-[1-[3-[1-oxo-4-(2,3,4,5,6-pentafluorophenyl)phthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H27F5N4O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0493779
|
N-[3-[1-[3-[4-(4-chlorophenyl)-6-fluoro-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H30ClFN4O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0527619
|
N-[3-[1-[3-(1-oxo-4-phenylphthalazin-2-yl)propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H32N4O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0127915
|
2-(4-fluorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26FN3O3S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0066594
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-[[methyl-[(3-methyloxetan-3-yl)methyl]amino]methyl]phenoxy]azetidin-1-yl]methanone
Show/Hide
|
C26H30N4O5
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0442604
|
6-[4-(methyloxy)phenyl]-3-[2-(4-morpholinylmethyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H24N4O3S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0376428
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylindazol-5-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0553745
|
6-(4-chlorophenyl)-3-[6-(hydroxymethyl)-2-naphthalenyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H15ClN2O2S
|
1
|
| 1 |
IC50 = 31.6 nM
|
|
|
|
CP0376174
|
3-(2-amino-3H-benzimidazol-5-yl)-6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C19H12ClN5OS
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0532420
|
6-(4-chlorophenyl)-3-(2-methyl-1-phenylbenzimidazol-5-yl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C26H17ClN4OS
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0541284
|
6-(4-chlorophenyl)-3-[2-(2-methoxyethylamino)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C22H18ClN5O2S
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0475744
|
N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-4-(pentanoylamino)benzamide
Show/Hide
|
C27H32N4O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0206374
|
2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)acetamide
Show/Hide
|
C23H27ClN4O2
|
2
|
| 1 |
IC50 = 33 nM
|
|
|
| 2 |
IC50 = 807 nM
|
|
|
|
CP0457413
|
4-(4-chlorophenyl)-N-[6-[[ethylcarbamoyl(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C28H28ClN3O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0403726
|
N-[3-[1-[3-[4-(4-cyanophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H31N5O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0095792
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(1,4-oxazepan-4-ylmethyl)phenoxy]azetidin-1-yl]methanone
Show/Hide
|
C25H28N4O5
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0356965
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(pyrrolidin-1-ylmethyl)phenoxy]azetidin-1-yl]methanone
Show/Hide
|
C24H26N4O4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0469560
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[4-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
Show/Hide
|
C22H18F3N3O2S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0534663
|
4-[(4-fluorophenyl)methoxy]-1-(3-methyl-2-propylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C23H22FN3O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0550721
|
4-(4-fluorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide
Show/Hide
|
C26H29FN4O
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0214541
|
[3-[4-[[methyl-[(3-methyloxetan-3-yl)methyl]amino]methyl]phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C25H28N4O4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0431626
|
4-[(4-chlorophenyl)methoxy]-1-(2,3-dimethylindazol-5-yl)pyridin-2-one
Show/Hide
|
C21H18ClN3O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0385724
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0408817
|
3-[2-(4-morpholinylmethyl)-6-quinolinyl]-6-[4-(trifluoromethyl)phenyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H21F3N4O2S
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0518095
|
6-(4-chlorophenyl)-3-[2-({4-[3-(4-morpholinyl)propyl]-1-piperazinyl}methyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C33H35ClN6O2S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0541023
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-one
Show/Hide
|
C22H19ClN4O2
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
|
CP0566686
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-ethylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C24H22ClN3O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0442430
|
6-(4-chlorophenyl)-3-[2-(morpholin-4-ylmethyl)-1-benzothien-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H20ClN3O2S2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0453232
|
3-[4-(4-chlorophenyl)phenyl]-N-[4-(piperidin-1-ylmethyl)phenyl]propanamide
Show/Hide
|
C27H29ClN2O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0045532
|
1-(2-cyclopropyl-3-methylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
Show/Hide
|
C22H18F3N3O2S
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
IC50 = 79 nM
|
|
|
|
CP0434055
|
1-(3,5-Dichloro-phenyl)-3-[4-(4-pyridin-3-yl-phenyl)-piperidin-4-ylmethyl]-urea
Show/Hide
|
C24H24Cl2N4O
|
2
|
| 1 |
IC50 = 39 nM
|
|
|
| 2 |
Ki = 39 nM
|
|
|
|
CP0499924
|
6-(4-bromophenyl)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H21BrN4O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0527618
|
N-[3-[1-[3-[3-(4-chlorophenyl)-4,5-dimethyl-6-oxopyridazin-1-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C28H33ClN4O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0514024
|
2-(4-chlorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26ClN3O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0428200
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-(morpholin-4-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C26H30N4O5
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 71 nM
|
|
|
|
CP0493956
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C23H20FN3O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0549159
|
N-[(1R)-1-(4-methoxyphenyl)ethyl]-4-[[1-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]benzamide
Show/Hide
|
C33H36N2O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0535732
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
Show/Hide
|
C22H18F3N3O2S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0397321
|
3-(3-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)propyl)-1-(3-fluorophenyl)-1-p-tolylurea
Show/Hide
|
C30H34FN3O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0474041
|
3-(3-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)propyl)-1,1-dip-tolylurea
Show/Hide
|
C31H37N3O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0179464
|
(R,E)-N-(1-cinnamylpyrrolidin-3-yl)-3,5-dimethoxybenzamide
Show/Hide
|
C22H26N2O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0514947
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0443538
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-[(4-methylpiperazin-1-yl)methyl]phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C27H33N5O4
|
2
|
| 1 |
IC50 = 42 nM
|
|
|
| 2 |
IC50 = 70 nM
|
|
|
|
CP0061230
|
(5-phenyl-1,3,4-oxadiazol-2-yl)-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0386236
|
1-(2-cyclopropyl-3-methylindazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C23H20FN3O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0172424
|
N-[2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0360644
|
[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C25H27FN4O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0385723
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0434056
|
4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-(pyrrolidine-1-carbonyl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
Show/Hide
|
C33H29F4N5O
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0441478
|
(Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methyl)pyridin-3-yl)methyl)-5-methyl-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-6(5H)-one
Show/Hide
|
C27H28F2N4O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0133641
|
US8685958, 12
Show/Hide
|
C26H28N4O5
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0499816
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-phenylmethoxypyridin-2-one
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0394860
|
1-(2-acetyl-1,3,4,5-tetrahydro-2-benzazepin-8-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C27H33ClN2O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0541020
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C23H20FN3O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0489269
|
4-(4-methoxyphenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide
Show/Hide
|
C27H32N4O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0386059
|
1-(2-ethyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C22H20FN3O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0104799
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
Show/Hide
|
C22H27F3N4O4
|
3
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
| 3 |
IC50 = 260 nM
|
|
|
|
CP0435700
|
2-Methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
Show/Hide
|
C29H34N4O4
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0104797
|
2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide
Show/Hide
|
C23H25ClN4O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0499146
|
ethyl N-[[6-[[4-(4-chlorophenyl)benzoyl]amino]-3,4-dihydronaphthalen-2-yl]methyl]-N-methylcarbamate
Show/Hide
|
C28H27ClN2O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0441255
|
N-[3-[1-[3-[4-(4-bromophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31BrN4O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0467480
|
N-[3-[1-[3-[4-(4-chloro-2-fluorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H30ClFN4O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0481494
|
2-(4-ethylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0499292
|
2-(3,4-difluorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H25F2N3O3S
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0507796
|
2-(3-chloro-4-fluorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H25ClFN3O3S
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0066589
|
[4-[4-[(3-hydroxypyrrolidin-1-yl)methyl]phenoxy]piperidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C25H28N4O4
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0284315
|
1-(2-Biphenyl-4-yl-4-cyclopentylamino-butyl)-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C28H31Cl2N3O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0522287
|
4-(Benzyloxy)-1-(4-{[1-(dimethylamino)propan-2-yl]-oxy}phenyl)pyridin-2(1H)-one
Show/Hide
|
C23H26N2O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0337243
|
3,4-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-yl)benzamide
Show/Hide
|
C23H22F2N2O
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0429695
|
3-(3-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)propyl)-1-(4-fluorophenyl)-1-p-tolylurea
Show/Hide
|
C30H34FN3O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0293160
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)pyridine-2-carboxamide
Show/Hide
|
C23H19FN4O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0439050
|
N-[2-(diethylamino)ethyl]-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
Show/Hide
|
C21H25F3N4O3
|
2
|
| 1 |
IC50 = 60 nM
|
|
|
| 2 |
IC50 = 250 nM
|
|
|
|
CP0428794
|
2-(2,4-difluorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H25F2N3O3S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0428795
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-(4-methylphenyl)sulfanyl-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O3S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0393454
|
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl)butan-1-one
Show/Hide
|
C26H32ClNO
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0356966
|
(5-phenyl-1,2-oxazol-3-yl)-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C26H29N3O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0179461
|
3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-yl)benzamide
Show/Hide
|
C25H28N2O3
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0394859
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]butan-1-one
Show/Hide
|
C27H33ClN2O3
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0408816
|
6-(4-chlorophenyl)-3-(6-quinolinyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C21H12ClN3OS
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0508803
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylpyrazolo[1,5-a]pyridin-5-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0132948
|
2-Methoxy-N-(3-morpholin-4-yl-propyl)-4-[3-(3-phenoxy-phenyl)-ureido]-benzamide
Show/Hide
|
C28H32N4O5
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0276446
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)pyrazine-2-carboxamide
Show/Hide
|
C22H18FN5O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0418771
|
1-(3-benzoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C32H35ClN2O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0481588
|
2-benzyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0173383
|
(3-((1R,4R,6R)-4-((5,6-difluoro-1H-benzo[d]imidazol-2-yl)(3-(4-methylpiperazin-1-yl)propyl)amino)bicyclo[4.1.0]heptan-1-yl)phenyl)methanol
Show/Hide
|
C29H37F2N5O
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0468317
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[[4-(trifluoromethyl)phenyl]methoxy]pyridin-2-one
Show/Hide
|
C24H20F3N3O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0475835
|
6-phenyl-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pyridine-3-carboxamide
Show/Hide
|
C26H24N4O
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0409754
|
4-[(5-chloropyridin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0483332
|
1-(2,3-dimethylindazol-5-yl)-4-[[4-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
Show/Hide
|
C20H16F3N3O2S
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0123343
|
(3-phenyl-1,2,4-oxadiazol-5-yl)-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0472704
|
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-phenylbenzamide
Show/Hide
|
C26H28N2O
|
2
|
| 1 |
IC50 = 76 nM
|
|
|
| 2 |
IC50 = 91 nM
|
|
|
|
CP0380258
|
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-(thiophen-2-ylmethoxy)pyridin-2-one
Show/Hide
|
C21H19N3O2S
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0392051
|
N-[5-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-2,3-dihydro-1H-inden-2-yl]acetamide
Show/Hide
|
C26H31ClN2O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0386058
|
1-(2,3-dimethylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0414880
|
1-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
Show/Hide
|
C21H19N3O2
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0429040
|
2-(2-chloro-4-fluorophenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H25ClFN3O3S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0527746
|
2-[(4-fluorophenyl)methyl]-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H28FN3O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0527747
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-(4-methylphenyl)-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0499943
|
5-(4-((dimethylamino)methyl)phenethyl)-N-(4-fluorophenyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
Show/Hide
|
C24H26FN5O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0466561
|
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-propylphenyl)benzamide
Show/Hide
|
C29H34N2O
|
2
|
| 1 |
IC50 = 84 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0207081
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(5-methylpyridin-2-yl)benzamide
Show/Hide
|
C24H22N4O
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0549408
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-propylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C25H24ClN3O2
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0476204
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-fluorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C27H33FN2O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0442603
|
6-(4-chlorophenyl)-3-(2-{[methyl(phenyl)amino]methyl}-6-quinolinyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C29H21ClN4OS
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0280589
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(5-fluoropyridin-2-yl)benzamide
Show/Hide
|
C23H19FN4O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0431932
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-(4-propan-2-ylphenyl)-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C29H33N3O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0483333
|
1-(2,3-dimethylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
Show/Hide
|
C20H16F3N3O2S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0490511
|
1-[2-(cyclopropylmethyl)-3-methylbenzimidazol-5-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C24H22FN3O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0523516
|
N-[3-[1-[3-[4-(4-methylphenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34N4O2
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0067145
|
(3R)-1-[[4-[3-(6-phenoxypyridazin-3-yl)propoxy]phenyl]methyl]piperidin-3-ol
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0468318
|
5-[(4-chlorophenyl)methoxy]-2-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridazin-3-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0095786
|
[3-[3-fluoro-4-[(4-methylpiperazin-1-yl)methyl]phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Show/Hide
|
C24H26FN5O3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0086722
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(5-methylsulfonylpyridin-2-yl)benzamide
Show/Hide
|
C24H22N4O3S
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0276480
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-6-(4-fluorophenyl)pyridine-3-carboxamide
Show/Hide
|
C23H19FN4O
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0046032
|
2-[4-(4-chlorophenyl)phenoxy]-N-[4-(piperidin-1-ylmethyl)phenyl]acetamide
Show/Hide
|
C26H27ClN2O2
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0514948
|
2-(4-chlorophenyl)-6-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3,4-dihydro-2H-pyrano[3,2-c]pyridin-5-one
Show/Hide
|
C25H22ClN3O2
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0192973
|
N-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propyl]-4-(pyrrolidin-1-ylmethyl)aniline
Show/Hide
|
C25H30N4O
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0468327
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(thiophen-2-ylmethoxy)pyridin-2-one
Show/Hide
|
C21H19N3O2S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0537725
|
2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(4-pyrimidin-5-yl-phenyl)-methyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole
Show/Hide
|
C28H25F4N5
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0527533
|
N-[3-[1-[3-[4-(2-chlorophenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31ClN4O2
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0566898
|
4-[(4-chlorophenyl)methoxy]-1-(1,3-dimethylindazol-5-yl)pyridin-2-one
Show/Hide
|
C21H18ClN3O2
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0501118
|
6-(4-chlorophenyl)-3-[2-(4-methylpiperazin-1-yl)-3H-benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C24H21ClN6OS
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0485587
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-thiophen-2-ylthieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C23H23N3O3S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0302867
|
4-(5-chloropyridin-2-yl)-N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)benzamide
Show/Hide
|
C23H19ClN4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0440271
|
1-[7-[3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy]-1,2,4,5-tetrahydro-3-benzazepin-3-yl]ethanone
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0460838
|
4-phenyl-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide
Show/Hide
|
C26H30N4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0487250
|
N-[8-ethyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-4-(4-fluorophenyl)benzamide
Show/Hide
|
C29H28FN3O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0431927
|
2-(4-methoxyphenyl)sulfanyl-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O4S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0380257
|
4-[(3-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0307770
|
(R)-4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)methyl)-N-(1-(4-bromophenyl)ethyl)benzamide
Show/Hide
|
C29H31BrN2O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0573124
|
N-[(1R)-1-(4-bromophenyl)ethyl]-4-[[1-[(2,4-dimethylphenyl)methyl]piperidin-4-yl]methyl]benzamide
Show/Hide
|
C30H35BrN2O
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0283763
|
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
Show/Hide
|
C23H23FN2O
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0207082
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[6-(trifluoromethyl)pyridin-3-yl]benzamide
Show/Hide
|
C24H19F3N4O
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0110658
|
1-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Show/Hide
|
C27H23F3N4O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0452271
|
4-(4-fluorophenyl)-N-[8-methoxy-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H26FN3O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0469562
|
1-(2,3-dimethylindazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0493778
|
N-[3-[1-[3-[3-(4-chlorophenyl)-6-oxopyridazin-1-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C26H29ClN4O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0481587
|
2-[(4-chlorophenyl)methyl]-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H28ClN3O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0407715
|
1-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0166575
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(6-fluoropyridin-3-yl)pyridine-2-carboxamide
Show/Hide
|
C22H18FN5O
|
1
|
| 1 |
IC50 = 121 nM
|
|
|
|
CP0108629
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(5-methoxypyridin-2-yl)benzamide
Show/Hide
|
C24H22N4O2
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0497557
|
(+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(3,4-difluorophenyl)-N-methyl-2-(pyrrolidin-1-yl)acetamide
Show/Hide
|
C28H35F2N3O2
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0456450
|
6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[3,2-d]pyrimidin-4-one
Show/Hide
|
C25H24ClN3O4
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0549160
|
3-[4-[[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-[1-(propan-2-ylsulfonylmethyl)piperidin-4-ylidene]methyl]phenyl]benzonitrile
Show/Hide
|
C31H28F4N4O2S
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0497234
|
Biphenyl-4-carboxylic acid [4-(1-benzyl-piperidin-4-ylcarbamoyl)-3-methoxy-phenyl]-amide
Show/Hide
|
C33H33N3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0514026
|
2-(4-ethenylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H29N3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0508802
|
1-(2,3-dimethylindazol-5-yl)-4-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methoxy]pyridin-2-one
Show/Hide
|
C19H15F3N4O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0434057
|
2-[(3'-cyano-biphenyl-4-yl)-(1-cyclopropylmethyl-piperidin-4-ylidene)-methyl]-1H-benzoimidazole-5-carbonitrile
Show/Hide
|
C31H27N5
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0564802
|
2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-methanesulfonyl-biphenyl-4-yl)-methyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole
Show/Hide
|
C31H29F4N3O2S
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0403725
|
N-[3-[1-[3-[1-oxo-4-[4-(trifluoromethyl)phenyl]phthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H31F3N4O2
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0432569
|
N-[2-(4-benzylpiperazin-1-yl)ethyl]-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C33H35N5O3
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 5820 nM
|
|
|
|
CP0440429
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C27H32N4O4
|
3
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 720 nM
|
|
|
| 3 |
IC50 = 880 nM
|
|
|
|
CP0425456
|
tert-butyl N-[[6-[[4-(4-chlorophenyl)benzoyl]amino]-3,4-dihydronaphthalen-2-yl]methyl]-N-methylcarbamate
Show/Hide
|
C30H31ClN2O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0501684
|
4-(3-chlorophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
Show/Hide
|
C26H27ClN2O
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 340 nM
|
|
|
|
CP0066538
|
1-[6-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Show/Hide
|
C27H24F2N4O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0356967
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[4-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]oxypiperidin-1-yl]methanone
Show/Hide
|
C25H29N5O4
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0399280
|
4-[(4-chlorophenyl)methoxy]-1-(2-ethyl-3-methylindazol-5-yl)pyridin-2-one
Show/Hide
|
C22H20ClN3O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0276531
|
(S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-2-yl)benzamide
Show/Hide
|
C26H29N3O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0500486
|
N-[3-[1-[3-[4-(4-methylsulfanylphenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34N4O2S
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0527069
|
4-[2-(4-Fluorophenoxy)ethoxy]-1-{4-[2-(pyrrolidin-1-yl)-ethoxy]phenyl}pyridin-2(1H)-one
Show/Hide
|
C25H27FN2O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0452309
|
6-[(4-chlorophenyl)methoxy]-3-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyrimidin-4-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0214542
|
(5-phenyl-1,2,4-oxadiazol-3-yl)-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0399283
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-1-methylindol-6-yl)pyridin-2-one
Show/Hide
|
C24H21ClN2O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0140703
|
(S)-1-(((S)-6-(4'-fluoro-N-methylbiphenyl-4-ylcarboxamido)-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-N,N-dimethylpyrrolidine-2-carboxamide
Show/Hide
|
C32H36FN3O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0353013
|
7-(4-fluorobenzoyl)-2-(4-(piperidin-1-ylmethyl)phenethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
Show/Hide
|
C28H30FN3O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0178182
|
4-[6-[3-[4-(piperidin-1-ylmethyl)anilino]propyl]pyridazin-3-yl]benzonitrile
Show/Hide
|
C26H29N5
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0066832
|
4-[(dimethylamino)methyl]-N-[3-[6-(4-methoxyphenyl)pyridazin-3-yl]propyl]aniline
Show/Hide
|
C23H28N4O
|
1
|
| 1 |
IC50 = 154 nM
|
|
|
|
CP0391791
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-[(4-methylphenyl)methyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0420422
|
4-[(2-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0280590
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(6-fluoropyridin-3-yl)pyrimidine-2-carboxamide
Show/Hide
|
C21H17FN6O
|
1
|
| 1 |
IC50 = 164 nM
|
|
|
|
CP0457213
|
N-[3-[1-[3-[4-(4-chlorophenyl)-1-oxo-5,6,7,8-tetrahydrophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H35ClN4O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0526876
|
4-hexanoyl-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C28H33N3O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0469563
|
1-(2,3-dimethylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
Show/Hide
|
C20H16F3N3O2S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0500485
|
N-[3-[1-[3-[4-(4-methoxyphenyl)-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34N4O3
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0425733
|
4-(Benzyloxy)-1-(4-{[1-(dimethylamino)-2-methylpropan-2-yl]oxy}phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H28N2O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0428796
|
2-(3,4-dimethylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0468316
|
2-[6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-3-methylimidazo[1,2-a]pyridin-2-yl]acetonitrile
Show/Hide
|
C22H17FN4O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0453233
|
1-[[4-[3-[6-(4-fluorophenyl)pyridazin-3-yl]propoxy]phenyl]methyl]piperidin-4-ol
Show/Hide
|
C25H28FN3O2
|
1
|
| 1 |
IC50 = 186 nM
|
|
|
|
CP0466399
|
[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl] 4-phenylbenzoate
Show/Hide
|
C26H27NO2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0399414
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butane-1,4-dione
Show/Hide
|
C27H31ClN2O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0507829
|
2-(2,3-dimethylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0407235
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-pyridin-4-ylthieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C24H24N4O3S
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0524456
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethylsulfanyl)phenyl]carbamoylamino]benzamide
Show/Hide
|
C22H27F3N4O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0462347
|
6-[4-(1-methylpropyl)phenyl]-3-[2-(4-morpholinylmethyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C30H30N4O2S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0259097
|
[3-[5-[(dimethylamino)methyl]pyridin-2-yl]oxyazetidin-1-yl]-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
Show/Hide
|
C21H23N5O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0449046
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-(4-propylphenyl)-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C29H33N3O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0443354
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-methylpyridin-2-one
Show/Hide
|
C24H22ClN3O2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0399279
|
4-[(4-chlorophenyl)methoxy]-1-(3-methyl-2-propylindazol-5-yl)pyridin-2-one
Show/Hide
|
C23H22ClN3O2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0108630
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-6-(6-fluoropyridin-3-yl)pyridine-3-carboxamide
Show/Hide
|
C22H18FN5O
|
1
|
| 1 |
IC50 = 217 nM
|
|
|
|
CP0146531
|
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[4-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]oxypiperidin-1-yl]methanone
Show/Hide
|
C25H29N5O4
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0564804
|
2-[2-[4-[(dimethylamino)methyl]phenyl]ethyl]-7-[(4-fluorophenyl)methyl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one
Show/Hide
|
C25H28FN3O
|
1
|
| 1 |
IC50 = 228 nM
|
|
|
|
CP0451829
|
2-(2,4-Dichloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-propionamide
Show/Hide
|
C25H28Cl2N4O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0466559
|
4-[4-[[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]carbamoyl]phenyl]benzoic acid
Show/Hide
|
C27H28N2O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0535734
|
1-(2,3-dimethylindazol-5-yl)-4-[[2-(trifluoromethyl)-1,3-thiazol-4-yl]methoxy]pyridin-2-one
Show/Hide
|
C19H15F3N4O2S
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0440430
|
N-[2-(diethylamino)ethyl]-2-ethoxy-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C28H34N4O4
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
IC50 = 1950 nM
|
|
|
|
CP0541022
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-2-ylmethoxy)pyridin-2-one
Show/Hide
|
C22H20N4O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0386061
|
1-(2-cyclobutyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C24H22FN3O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0497236
|
N-[(1-ethylpyrrolidin-2-yl)methyl]-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C27H30N4O3
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0498471
|
4-[3-(4-Bromo-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
Show/Hide
|
C21H27BrN4O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0485015
|
3-(4-Methoxy-phenyl)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-propionamide
Show/Hide
|
C25H30N4O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0407718
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-[4-(trifluoromethoxy)phenoxy]pyridin-2-one
Show/Hide
|
C23H18F3N3O3
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0309254
|
(R)-4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)methyl)-N-(1-(4-methoxyphenyl)ethyl)benzamide
Show/Hide
|
C30H34N2O4
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0440270
|
1-(6-acetyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C24H29ClN2O2S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0407897
|
5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)methyl)piperidin-4-yl)-1H-indazol-3-amine
Show/Hide
|
C21H23ClN4O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0527994
|
1-[2-(4'-Chloro-biphenyl-4-yl)-4-cyclopentylamino-butyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C28H30Cl3N3O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0469222
|
2-Benzyl-8-(2-{1-[4-(4,5-dihydro-1H-imidazol-2-yl)-benzyl]-piperidin-4-yl}-ethoxy)-2,3,4,5-tetrahydro-benzo[c]azepin-1-one
Show/Hide
|
C34H40N4O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0385198
|
2-(2,5-dimethylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0082131
|
(S)-N-(6-((4-acetylpiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-5-(4-fluorophenyl)-N-methylpicolinamide
Show/Hide
|
C30H33FN4O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0378250
|
1-(3,5-Dichloro-phenyl)-3-(1-methyl-4-p-tolyl-piperidin-4-ylmethyl)-urea
Show/Hide
|
C21H25Cl2N3O
|
2
|
| 1 |
IC50 = 300 nM
|
|
|
| 2 |
Ki = 300 nM
|
|
|
|
CP0511305
|
2-(4-tert-butylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C30H35N3O3
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0312797
|
5,6-difluoro-N-((1R,3R,6R)-6-(3-((4-methylpiperazin-1-yl)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine
Show/Hide
|
C34H47F2N7
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0528653
|
2-(4-methoxyphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O4
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0425455
|
4-(4-aminophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
Show/Hide
|
C26H29N3O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0486377
|
Biphenyl-4-carboxylic acid [4-(2-diethylamino-ethylcarbamoyl)-3-methoxy-phenyl]-amide
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0459931
|
4-(4-cyanophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
Show/Hide
|
C27H27N3O
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0466560
|
4-(4-chlorophenyl)-N-[6-[[methoxy(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
Show/Hide
|
C26H25ClN2O2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0457215
|
N-[3-[1-[3-[1-oxo-4-(4-propan-2-ylphenyl)phthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C33H38N4O2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0549396
|
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-2-one
Show/Hide
|
C22H19ClN4O2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0110906
|
5,6-difluoro-N-(3-(4-methylpiperazin-1-yl)propyl)-N-((1R,3R,6R)-6-(3-(piperidin-1-ylmethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1H-benzo[d]imidazol-2-amine
Show/Hide
|
C34H46F2N6
|
1
|
| 1 |
IC50 = 405 nM
|
|
|
|
CP0511036
|
2-[(3-fluorophenyl)methyl]-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H28FN3O3
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0565750
|
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-propan-2-ylphenyl)methoxy]pyridin-2-one
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0441370
|
N-[3-[1-[3-[4-[4-(dimethylamino)phenyl]-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C32H37N5O2
|
1
|
| 1 |
IC50 = 423 nM
|
|
|
|
CP0110657
|
1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Show/Hide
|
C28H25F3N4O2
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0488430
|
2-(4-chlorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26ClN3O3
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0456617
|
N-[2-[4-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]phenyl]ethyl]acetamide
Show/Hide
|
C25H31ClN2O2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0537892
|
6-(4-cyano)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]thieno-[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C27H21N5O2S
|
1
|
| 1 |
IC50 = 478 nM
|
|
|
|
CP0467431
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(2-chlorophenyl)piperazin-1-yl]butan-1-one
Show/Hide
|
C26H32ClN3O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0432697
|
5-(4-((diethylamino)methyl)phenethyl)-4-oxo-N-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
Show/Hide
|
C27H30F3N5O2
|
1
|
| 1 |
IC50 = 497 nM
|
|
|
|
CP0495943
|
6-(4-fluorophenyl)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H21FN4O2S
|
1
|
| 1 |
IC50 = 501 nM
|
|
|
|
CP0537891
|
6-[4-(1,1-dimethylethyl)phenyl]-3-[2-(4-morpholinylmethyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C30H30N4O2S
|
1
|
| 1 |
IC50 = 501 nM
|
|
|
|
CP0449537
|
2-(2-chlorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26ClN3O3
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0448793
|
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C28H32N4O4
|
2
|
| 1 |
IC50 = 530 nM
|
|
|
| 2 |
IC50 = 3450 nM
|
|
|
|
CP0496899
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[methyl-[(4-phenoxyphenyl)carbamoyl]amino]benzamide
Show/Hide
|
C28H34N4O4
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0431935
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-[4-(trifluoromethyl)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H26F3N3O3
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0511116
|
1-(2-cyclopentyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
|
C25H24FN3O2
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0059282
|
(E)-3-[4-(4-chlorophenyl)phenyl]-N-methyl-N-[4-(piperidin-1-ylmethyl)phenyl]prop-2-enamide
Show/Hide
|
C28H29ClN2O
|
1
|
| 1 |
IC50 = 634 nM
|
|
|
|
CP0404725
|
Biphenyl-4-carboxylic acid [4-(3-dimethylamino-propylcarbamoyl)-3-methoxy-phenyl]-amide
Show/Hide
|
C26H29N3O3
|
2
|
| 1 |
IC50 = 640 nM
|
|
|
| 2 |
IC50 = 5290 nM
|
|
|
|
CP0464621
|
Biphenyl-4-carboxylic acid {4-[2-(4-benzyl-piperazin-1-yl)-ethylcarbamoyl]-3-methoxy-phenyl}-amide
Show/Hide
|
C34H36N4O3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0380414
|
4-(Biphenyl-4-ylmethoxy)-1-{4-[2-(pyrrolidin-1-yl)-ethoxy]phenyl}pyridin-2(1H)-one
Show/Hide
|
C30H30N2O3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0498590
|
4-[2-(4-Fluorophenyl)ethoxy]-1-{4-[2-(pyrrolidin-1-yl)-ethoxy]phenyl}pyridin-2(1H)-one
Show/Hide
|
C25H27FN2O3
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0379191
|
4-[3-(3,4-Dichloro-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
Show/Hide
|
C21H26Cl2N4O3
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0514025
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-[(2-methylphenyl)methyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0409387
|
N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]-3-(4-methoxyphenyl)propanamide
Show/Hide
|
C26H32N4O2
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0082124
|
N-[(2S)-6-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamide
Show/Hide
|
C29H31FN2O3S
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0501485
|
2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-propionamide
Show/Hide
|
C24H26Cl2N4O2
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0419615
|
3-[2-(4-morpholinylmethyl)-6-quinolinyl]-6-phenylthieno-[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H22N4O2S
|
1
|
| 1 |
IC50 = 794 nM
|
|
|
|
CP0501404
|
2-Methoxy-4-[3-(4-phenylamino-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
Show/Hide
|
C29H35N5O3
|
2
|
| 1 |
IC50 = 850 nM
|
|
|
| 2 |
IC50 = 1440 nM
|
|
|
|
CP0536648
|
N-[(2S)-6-[(dimethylamino)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methyl-5-pyridin-3-ylpyridine-2-carboxamide
Show/Hide
|
C25H28N4O
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
|
CP0247543
|
1-[[4-(4-chlorophenyl)phenyl]methyl]-3-[4-(piperidin-1-ylmethyl)phenyl]urea
Show/Hide
|
C26H28ClN3O
|
1
|
| 1 |
IC50 = 899 nM
|
|
|
|
CP0467429
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(2-methylphenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C28H36N2O2
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0316603
|
N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamide
Show/Hide
|
C23H24N2O
|
1
|
| 1 |
IC50 = 948 nM
|
|
|
|
CP0501210
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[(4-methylsulfanylphenyl)carbamoylamino]benzamide
Show/Hide
|
C22H30N4O3S
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0443353
|
3-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0293159
|
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C24H19F3N4O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0101606
|
[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C25H27ClN4O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0543604
|
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-(2-methylphenyl)-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O3
|
1
|
| 1 |
IC50 = 1040 nM
|
|
|
|
CP0263177
|
1-[4-[1,4']Bipiperidinyl-1'-yl-2-(3,4-dichloro-phenyl)-butyl]-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
|
C28H35Cl2F3N4O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0476205
|
1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(3-methylphenyl)piperidin-1-yl]butan-1-one
Show/Hide
|
C28H36N2O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0270975
|
(5-methyl-2-phenyl-1,3-oxazol-4-yl)-[4-[4-(pyrrolidin-1-ylmethyl)phenoxy]piperidin-1-yl]methanone
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0538450
|
6-(2-chlorophenyl)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H21ClN4O2S
|
1
|
| 1 |
IC50 = 1258 nM
|
|
|
|
CP0422292
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C26H27N3O5S2
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0512503
|
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-phenylphenyl)benzamide
Show/Hide
|
C32H32N2O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0434058
|
4-[[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]methyl]-N-[(1S)-1-(4-bromophenyl)ethyl]benzamide
Show/Hide
|
C29H31BrN2O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0442435
|
6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]-N-[3-(1-pyrrolidinyl)propyl]-2-naphthalenecarboxamide
Show/Hide
|
C30H27ClN4O2S
|
1
|
| 1 |
IC50 = 1412 nM
|
|
|
|
CP0440428
|
4-(3-Biphenyl-4-yl-ureido)-N-(3-dimethylamino-propyl)-2-methoxy-benzamide
Show/Hide
|
C26H30N4O3
|
2
|
| 1 |
IC50 = 1480 nM
|
|
|
| 2 |
IC50 = 9100 nM
|
|
|
|
CP0503375
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-pyridin-3-ylthieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C24H24N4O3S
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0383010
|
4-butylsulfonyl-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
Show/Hide
|
C26H31N3O3S
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0299248
|
4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)methyl)-N-(1-phenylpropyl)benzamide
Show/Hide
|
C30H34N2O3
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0497235
|
N-[(1-ethylpyrrolidin-2-yl)methyl]-4-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]benzamide
Show/Hide
|
C28H28N4O3
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0527745
|
2-[(4-tert-butylphenyl)methyl]-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C31H37N3O3
|
1
|
| 1 |
IC50 = 1910 nM
|
|
|
|
CP0432568
|
N-[3-(dimethylamino)propyl]-2-methoxy-4-[(4-phenoxybenzoyl)amino]benzamide
Show/Hide
|
C26H29N3O4
|
1
|
| 1 |
IC50 = 1920 nM
|
|
|
|
CP0430898
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[(4-phenoxybenzoyl)amino]benzamide
Show/Hide
|
C27H31N3O4
|
2
|
| 1 |
IC50 = 1970 nM
|
|
|
| 2 |
IC50 = 6810 nM
|
|
|
|
CP0431934
|
2-(2-ethylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C28H31N3O3
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0428797
|
2-(3-methoxyphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C27H29N3O4
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0404724
|
Biphenyl-4-carboxylic acid [4-(2-dimethylamino-ethylcarbamoyl)-3-methoxy-phenyl]-amide
Show/Hide
|
C25H27N3O3
|
2
|
| 1 |
IC50 = 2410 nM
|
|
|
| 2 |
IC50 = 12000 nM
|
|
|
|
CP0550929
|
N-[2-(diethylamino)ethyl]-4-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]benzamide
Show/Hide
|
C27H28N4O3
|
1
|
| 1 |
IC50 = 2450 nM
|
|
|
|
CP0497435
|
N-[2-(diethylamino)ethyl]-2-methoxy-4-[[3-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
Show/Hide
|
C22H27F3N4O4
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0541283
|
6-(4-chlorophenyl)-3-[2-(dimethylamino)-3-[(4-methoxyphenyl)methyl]benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C29H24ClN5O2S
|
1
|
| 1 |
IC50 = 2511.89 nM
|
|
|
|
CP0545392
|
4-(piperidin-1-ylmethyl)-N-[3-(6-pyridin-4-ylpyridazin-3-yl)propyl]aniline
Show/Hide
|
C24H29N5
|
1
|
| 1 |
IC50 = 2530 nM
|
|
|
|
CP0511037
|
2-(4-butylphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C30H35N3O3
|
1
|
| 1 |
IC50 = 2780 nM
|
|
|
|
CP0132420
|
((S)-1-(difluoro-1H-benzo[d]imidazol-2-yl)(3-(4-methylpiperazin-1-yl)propyl)amino)bicyclo[4.1.0]heptan-1-yl)benzyl)pyrrolidin-2-yl)methanol
Show/Hide
|
C34H46F2N6O
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0517675
|
2-(4-fluorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26FN3O3
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0453066
|
N-[4-[3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-oxothieno[3,2-d]pyrimidin-6-yl]phenyl]acetamide
Show/Hide
|
C27H28N4O4S
|
1
|
| 1 |
IC50 = 3162.28 nM
|
|
|
|
CP0497438
|
4-[3-(4-Cyano-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
Show/Hide
|
C22H27N5O3
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0509678
|
N-[2-(diethylamino)ethyl]-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 3500 nM
|
|
|
|
CP0110078
|
(S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)nicotinamide
Show/Hide
|
C28H29FN4O2
|
1
|
| 1 |
IC50 = 3500 nM
|
|
|
|
CP0432106
|
N-[2-[6-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyridin-3-yl]ethyl]-4-(cyclopropylmethoxy)benzamide
Show/Hide
|
C28H30F2N4O2
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0498472
|
4-[3-(3-Chloro-4-fluoro-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
Show/Hide
|
C21H26ClFN4O3
|
1
|
| 1 |
IC50 = 3900 nM
|
|
|
|
CP0529715
|
6-(3-chlorophenyl)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C26H21ClN4O2S
|
1
|
| 1 |
IC50 = 3980 nM
|
|
|
|
CP0456451
|
3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C19H21N3O3S
|
1
|
| 1 |
IC50 = 3981.07 nM
|
|
|
|
CP0444308
|
2-[6-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyridin-3-yl]-6-butoxy-3,4-dihydroisoquinolin-1-one
Show/Hide
|
C28H30F2N4O2
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0543605
|
2-(2-fluorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
Show/Hide
|
C26H26FN3O3
|
1
|
| 1 |
IC50 = 4130 nM
|
|
|
|
CP0529713
|
6-(4-chlorophenyl)-3-[2-[(dimethylamino)methyl]-4-(methylsulfonyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C24H23ClN4O4S2
|
1
|
| 1 |
IC50 = 4168 nM
|
|
|
|
CP0573126
|
N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-3,5-dihydroxybenzamide
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C20H22N2O5
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1
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| 1 |
IC50 = 4300 nM
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CP0506244
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[(3-methylsulfanylphenyl)carbamoylamino]benzamide
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C22H30N4O3S
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1
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| 1 |
IC50 = 4700 nM
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CP0439046
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4-[3-(3,5-Dichloro-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
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C21H26Cl2N4O3
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1
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| 1 |
IC50 = 4800 nM
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CP0562528
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N-[(1R)-1-(4-bromophenyl)ethyl]-4-[[1-[(4-phenylphenyl)methyl]piperidin-4-yl]methyl]benzamide
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C34H35BrN2O
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1
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| 1 |
IC50 = 5100 nM
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CP0391809
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2-(3-chlorophenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
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C26H26ClN3O3
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1
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| 1 |
IC50 = 5650 nM
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CP0495007
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[[methyl-(4-phenoxyphenyl)carbamoyl]amino]benzamide
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C28H34N4O4
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1
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| 1 |
IC50 = 5800 nM
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CP0399893
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(2,2,2-trifluoroacetyl)phenyl]carbamoylamino]benzamide
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C23H27F3N4O4
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1
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| 1 |
IC50 = 5900 nM
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CP0485016
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N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]-2-(3-methylphenoxy)acetamide
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C25H30N4O2
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1
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| 1 |
IC50 = 6600 nM
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CP0434060
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1-[4-[1,4']Bipiperidinyl-1'-yl-2-(3,4-dichloro-phenyl)-butyl]-3-m-tolyl-urea
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C28H38Cl2N4O
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1
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| 1 |
IC50 = 6800 nM
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CP0433040
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6-(4-chlorophenyl)-3-[2-[(dimethylamino)methyl]-4-(phenylsulfonyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]thieno[3,2-d]pyrimidin-4(3H)-one
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C29H25ClN4O4S2
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1
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| 1 |
IC50 = 6918 nM
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CP0391792
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2-(2-methoxyphenyl)-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5H-pyrrolo[3,4-b]pyridin-7-one
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C27H29N3O4
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1
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| 1 |
IC50 = 7110 nM
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CP0528348
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[[3-(trifluoromethyl)phenyl]carbamoylamino]benzamide
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C22H27F3N4O3
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1
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| 1 |
IC50 = 7900 nM
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CP0421103
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N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]-2-pyridin-4-ylsulfanylacetamide
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C23H27N5OS
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1
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| 1 |
IC50 = 8200 nM
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CP0506243
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4-[3-(2-Bromo-4-trifluoromethoxy-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
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C22H26BrF3N4O4
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1
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| 1 |
IC50 = 8800 nM
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CP0521127
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2-Methoxy-4-[3-(2-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide
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C29H34N4O4
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1
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| 1 |
IC50 > 10000 nM
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CP0518078
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6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]-2-naphthalenecarboxylic acid
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C23H13ClN2O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0538443
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6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylcarbonyl)-2-naphthalenyl]thieno[3,2-d]pyrimidin-4(3H)-one
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C27H20ClN3O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0553744
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6-(4-chlorophenyl)-3-(2-naphthalenyl)thieno[3,2-d]pyrimidin-4(3H)-one
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C22H13ClN2OS
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1
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| 1 |
IC50 > 10000 nM
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CP0425470
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N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-3-phenylbenzamide
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C26H28N2O
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1
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| 1 |
IC50 = 10000 nM
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CP0499102
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N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
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C20H24N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0501676
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N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-2-phenylbenzamide
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C26H28N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0481589
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4-[6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-7-oxo-5H-pyrrolo[3,4-b]pyridin-2-yl]benzonitrile
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C27H26N4O3
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1
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| 1 |
IC50 = 10000 nM
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CP0507831
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6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-phenyl-5H-pyrrolo[3,4-b]pyridin-7-one
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C26H27N3O3
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1
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| 1 |
IC50 = 10000 nM
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CP0363512
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3-Phenyl-propynoic acid [4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-amide
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C21H23N3O
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1
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| 1 |
IC50 > 10000 nM
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CP0496852
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N-[2-(diethylamino)ethyl]-N-methyl-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
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C27H32N4O3
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1
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| 1 |
IC50 = 11000 nM
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CP0392707
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4-fluoro-N-[[1-[(4-methoxy-2,3-dimethylphenyl)methyl]piperidin-3-yl]methyl]benzamide
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C23H29FN2O2
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1
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| 1 |
IC50 = 11000 nM
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CP0334693
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4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)methyl)-N-(2-phenylpropyl)benzamide
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C30H34N2O3
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1
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| 1 |
IC50 = 11765 nM
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CP0494987
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4-[3-(4-Acetyl-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
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C23H30N4O4
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1
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| 1 |
IC50 = 13000 nM
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CP0357139
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4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)methyl)-N-(cyclopropylmethyl)benzamide
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C25H30N2O3
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1
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| 1 |
IC50 = 14000 nM
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CP0430018
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N-[2-(diethylamino)ethyl]-4-[(4-fluorophenyl)carbamoylamino]-2-methoxybenzamide
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C21H27FN4O3
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1
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| 1 |
IC50 = 15800 nM
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CP0527995
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4-[[1-(1,3-benzodioxol-4-ylmethyl)piperidin-4-yl]methyl]-N-[(1R)-1-(4-bromophenyl)ethyl]benzamide
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C29H31BrN2O3
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1
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| 1 |
IC50 = 17380 nM
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CP0524449
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N-[2-(diethylamino)ethyl]-4-[(3,5-dimethoxyphenyl)carbamoylamino]-2-methoxybenzamide
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C23H32N4O5
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1
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| 1 |
IC50 = 18000 nM
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CP0527993
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(3,5-dimethoxyphenyl)-[9-[(3-methylphenyl)methyl]-2,9-diazaspiro[4.5]decan-2-yl]methanone
Show/Hide
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C25H32N2O3
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1
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| 1 |
IC50 = 18000 nM
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CP0403173
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N-(1-benzylpiperidin-4-yl)-2-(4-chloro-2-methylphenoxy)acetamide
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C21H25ClN2O2
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1
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| 1 |
IC50 = 23000 nM
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CP0403174
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N-(1-benzylpiperidin-4-yl)-5-bromo-3-methyl-1-benzofuran-2-carboxamide
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C22H23BrN2O2
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1
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| 1 |
IC50 = 23000 nM
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CP0439949
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N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide
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C19H21FN2O
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1
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| 1 |
IC50 = 43000 nM
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CP0541556
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Biphenyl-4-carboxylic acid [4-(2-dimethylamino-ethylcarbamoyl)-phenyl]-amide
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C24H25N3O2
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1
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| 1 |
IC50 > 100000 nM
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CP0405819
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[2-oxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]benzamide
Show/Hide
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C29H34N4O4
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1
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| 1 |
IC50 > 100000 nM
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CP0497403
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N-[2-(diethylamino)ethyl]-2-methoxy-N-methyl-4-[(4-phenoxyphenyl)carbamoylamino]benzamide
Show/Hide
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C28H34N4O4
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1
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| 1 |
IC50 > 100000 nM
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CP0497405
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5-Chloro-N-(2-diethylamino-ethyl)-2-methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-benzamide
Show/Hide
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C27H31ClN4O4
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1
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| 1 |
IC50 > 100000 nM
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CP0515350
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N-[2-(diethylamino)ethyl]-2-methoxy-4-(phenylcarbamoylamino)benzamide
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C21H28N4O3
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1
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| 1 |
IC50 > 100000 nM
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CP0524487
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N-[2-(diethylamino)ethyl]-2-methoxy-4-[methyl-[methyl-(4-phenoxyphenyl)carbamoyl]amino]benzamide
Show/Hide
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C29H36N4O4
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1
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| 1 |
IC50 > 100000 nM
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CP0378847
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methyl N-[2-(diethylamino)ethyl]-N-[4-(2-oxo-4-phenylmethoxypyridin-1-yl)phenyl]carbamate
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C26H31N3O4
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1
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| 1 |
IC50 > 1000 nM
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CP0478496
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4-(4-Fluorophenyl)-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyridin-2(1H)-one
Show/Hide
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C24H25FN2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0522224
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4-(4-Fluorophenoxy)-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyridin-2(1H)-one
Show/Hide
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C24H25FN2O3
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1
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| 1 |
IC50 > 1000 nM
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CP0498830
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N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-phenylbenzenesulfonamide
Show/Hide
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C25H28N2O2S
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1
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| 1 |
IC50 > 1000 nM
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CP0526609
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6-[(dimethylamino)methyl]-N-[(4-phenylphenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine
Show/Hide
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C26H30N2
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1
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| 1 |
IC50 > 1000 nM
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CP0393411
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[ethyl(propyl)amino]butan-1-one
Show/Hide
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C21H32N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0427932
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-(4-ethylpiperazin-1-yl)butan-1-one
Show/Hide
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C22H33N3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0452186
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[benzyl(methyl)amino]butan-1-one
Show/Hide
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C24H30N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0456615
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-(4-phenylpiperazin-1-yl)butan-1-one
Show/Hide
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C26H33N3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0476206
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-morpholin-4-ylbutan-1-one
Show/Hide
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C20H28N2O3
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1
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| 1 |
IC50 > 1000 nM
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CP0476207
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(3-chlorophenyl)piperazin-1-yl]butan-1-one
Show/Hide
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C26H32ClN3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0495849
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-pyrrolidin-1-ylbutan-1-one
Show/Hide
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C20H28N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0495850
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[methyl(naphthalen-1-ylmethyl)amino]butan-1-one
Show/Hide
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C28H32N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0495990
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-(3,4-dihydro-1H-isoquinolin-2-yl)butan-1-one
Show/Hide
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C25H30N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0495991
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperazin-1-yl]butan-1-one
Show/Hide
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C26H32ClN3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0523755
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-(4-benzylpiperidin-1-yl)butan-1-one
Show/Hide
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C28H36N2O2
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1
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| 1 |
IC50 > 1000 nM
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CP0523756
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1-(3-acetyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-(4-benzylpiperazin-1-yl)butan-1-one
Show/Hide
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C27H35N3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0407717
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1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[4-(trifluoromethoxy)phenoxy]pyridin-2-one
Show/Hide
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C23H18F3N3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0443347
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1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyrimidin-5-ylmethoxy)pyridin-2-one
Show/Hide
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C21H19N5O2
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1
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| 1 |
IC50 > 1000 nM
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CP0443348
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4-[(4-fluorophenyl)methoxy]-1-[2-(methoxymethyl)-3-methylimidazo[1,2-a]pyridin-6-yl]pyridin-2-one
Show/Hide
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C22H20FN3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0443349
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4-[(4-fluorophenyl)methoxy]-1-[2-(hydroxymethyl)-3-methylimidazo[1,2-a]pyridin-6-yl]pyridin-2-one
Show/Hide
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C21H18FN3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0443355
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6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-N,N,3-trimethylimidazo[1,2-a]pyridine-2-carboxamide
Show/Hide
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C23H21FN4O3
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1
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| 1 |
IC50 > 1000 nM
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CP0443357
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1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-3-ylmethoxy)pyridin-2-one
Show/Hide
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C22H20N4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0452304
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6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-3-methylimidazo[1,2-a]pyridine-2-carbonitrile
Show/Hide
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C21H15FN4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0452345
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1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-4-ylmethoxy)pyridin-2-one
Show/Hide
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C22H20N4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0468319
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1-(2-acetyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
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C22H18FN3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0505228
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1-[2-(cyclopropanecarbonyl)-3-methylimidazo[1,2-a]pyridin-6-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
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C24H20FN3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0541019
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N-(2-cyclopropyl-3-methylindolizin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
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C21H19F3N2O3
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1
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| 1 |
IC50 > 1000 nM
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CP0541024
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N-(2,3-dimethyl-1-benzofuran-5-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
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C19H16F3NO4
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1
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| 1 |
IC50 > 1000 nM
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CP0380256
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1-[2-(2,2-dimethylpropyl)-3-methylbenzimidazol-5-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
Show/Hide
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C25H26FN3O2
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1
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| 1 |
IC50 > 1000 nM
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CP0386057
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4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyrimidin-6-yl)pyridin-2-one
Show/Hide
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C22H19ClN4O2
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1
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| 1 |
IC50 > 1000 nM
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CP0566685
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4-[(5-chloropyrimidin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
Show/Hide
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C21H18ClN5O2
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1
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| 1 |
IC50 > 1000 nM
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CP0523677
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1-[6-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyridin-3-yl]-3-(3-phenylpropyl)pyrazin-2-one
Show/Hide
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C28H27F2N5O
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1
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| 1 |
IC50 > 3000 nM
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CP0376595
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N-[3-(6-methoxypyridazin-3-yl)propyl]-4-(piperidin-1-ylmethyl)aniline
Show/Hide
|
C20H28N4O
|
1
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| 1 |
IC50 > 3000 nM
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CP0562521
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3-(3-chloro-4-fluorophenyl)-1-[(1S,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-(2-pyridin-2-ylethyl)urea
Show/Hide
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C27H27ClFN3O3S
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1
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| 1 |
IC50 > 3000 nM
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CP0499212
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-isopropyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
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C29H30Cl2N4O
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1
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| 1 |
Ki = 0.45 nM
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CP0436380
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopentyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
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C31H32Cl2N4O
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1
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| 1 |
Ki = 0.63 nM
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CP0500733
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1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(3'-cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-urea
Show/Hide
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C28H26ClF3N4O
|
1
|
| 1 |
Ki = 0.98 nM
|
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CP0901862
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1-(4-Bromo-3-methoxy-phenyl)-4-((1S,2S)-2-phenyl-cyclopropylmethyl)-piperazine
Show/Hide
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C21H25BrN2O
|
1
|
| 1 |
Ki < 1 nM
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CP0427254
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-((2S)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl)ethyl)urea
Show/Hide
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C28H33Cl2N5O2
|
1
|
| 1 |
Ki = 1.2 nM
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CP0436390
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C27H26Cl2N4O
|
1
|
| 1 |
Ki = 1.4 nM
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CP0483614
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-(3,4-difluoro-phenyl)-urea
Show/Hide
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C27H26F2N4O
|
1
|
| 1 |
Ki = 1.4 nM
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CP0431604
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-(3-cyano-phenyl)-urea
Show/Hide
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C28H27N5O
|
1
|
| 1 |
Ki = 1.5 nM
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CP0458888
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-(((S)-1-hydroxypropan-2-yl)(isopropyl)amino)ethyl)urea
Show/Hide
|
C28H35Cl2N5O2
|
1
|
| 1 |
Ki = 1.6 nM
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CP0486157
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-((2-hydroxyethyl)(isopropyl)amino)ethyl)urea
Show/Hide
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C27H33Cl2N5O2
|
1
|
| 1 |
Ki = 1.6 nM
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CP0425172
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1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(4-piperidin-1-ylbutyl)urea
Show/Hide
|
C30H34F4N4O
|
1
|
| 1 |
Ki = 1.6 nM
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CP0445886
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1-[(1S,2R,5S)-5-(4-fluorophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C28H33F5N4O
|
1
|
| 1 |
Ki = 1.8 nM
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CP0458890
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-(isopropylamino)ethyl)urea
Show/Hide
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C25H29Cl2N5O
|
1
|
| 1 |
Ki = 1.9 nM
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CP0221174
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3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)-1-((1S,2R,5S)-5-(pyridin-3-yl)bicyclo[3.1.0]hexan-2-yl)urea
Show/Hide
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C26H33ClFN5O
|
1
|
| 1 |
Ki = 2 nM
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CP0395034
|
N-[3-[4-[4-[[(3,5-dichlorophenyl)carbamoylamino]methyl]-1-methylpiperidin-4-yl]phenyl]phenyl]acetamide
Show/Hide
|
C28H30Cl2N4O2
|
1
|
| 1 |
Ki = 2.1 nM
|
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CP0427528
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)-3-(3-fluorophenyl)urea
Show/Hide
|
C29H37FN4O
|
1
|
| 1 |
Ki = 2.1 nM
|
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CP0492599
|
1-(3,5-Dichloro-phenyl)-3-[1-methanesulfonyl-4-(4-pyridin-3-yl-phenyl)-piperidin-4-ylmethyl]-urea
Show/Hide
|
C25H26Cl2N4O3S
|
1
|
| 1 |
Ki = 2.2 nM
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CP0408569
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1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[4-(4-methylpiperazin-1-yl)butyl]urea
Show/Hide
|
C30H35F4N5O
|
1
|
| 1 |
Ki = 2.2 nM
|
|
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CP0497154
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1-((3R,6S)-6-(3-(aminomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H40ClFN4O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
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CP0468545
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1-[(1S,2R,5S)-5-(3-fluorophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C28H33F5N4O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
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CP0437115
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1-((3R,6S)-6-(3-(aminomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C27H35Cl2N5O3S
|
1
|
| 1 |
Ki = 2.4 nM
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CP0160698
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1-((1S,2R,5S)-5-(3-acetamidophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
|
C29H37ClFN5O2
|
1
|
| 1 |
Ki = 2.5 nM
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CP0527085
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1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(4-morpholin-4-ylbutyl)urea
Show/Hide
|
C29H32F4N4O2
|
1
|
| 1 |
Ki = 2.5 nM
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CP0393297
|
1-[4-(3'-Cyano-biphenyl-4-yl)-1-ethyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C28H28Cl2N4O
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
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CP0394746
|
1-[4-(3'-Chloro-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
Show/Hide
|
C26H26Cl3N3O
|
1
|
| 1 |
Ki = 2.6 nM
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|
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CP0256769
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1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
|
C29H33F4N5O
|
1
|
| 1 |
Ki = 2.7 nM
|
|
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CP0379069
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)-3-(3-nitrophenyl)urea
Show/Hide
|
C29H37N5O3
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
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CP0424354
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,4-difluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H36F2N4O
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
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CP0445887
|
3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[(1S,2R,5S)-5-(4-methoxyphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C29H36F4N4O2
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
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CP0436555
|
3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[(1S,2R,5S)-5-(3-methoxyphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C29H36F4N4O2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
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CP0432852
|
3-(2,6-dichloropyridin-4-yl)-1-((3R,6S)-6-(3-((dimethylamino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C29H39Cl2N5O3S
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
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CP0495931
|
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-fluorophenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C27H33ClF2N4O
|
1
|
| 1 |
Ki = 3.3 nM
|
|
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CP0496547
|
1-[(1S,2R,5S)-5-(4-cyano-3-fluorophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C29H32F5N5O
|
1
|
| 1 |
Ki = 3.5 nM
|
|
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CP0453665
|
3-(3-chloro-4-fluorophenyl)-1-((1R,3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
|
C29H35ClFN5O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
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CP0446625
|
1-[(1S,2R,5S)-5-(3-cyano-4-fluorophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C29H32F5N5O
|
1
|
| 1 |
Ki = 4 nM
|
|
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CP0465112
|
3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-((E)-(methoxyimino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
|
C30H40ClFN4O2
|
1
|
| 1 |
Ki = 4.1 nM
|
|
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CP0425173
|
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-1-(2-piperidin-1-ylethyl)urea
Show/Hide
|
C27H30ClFN4O
|
1
|
| 1 |
Ki = 4.1 nM
|
|
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CP0445740
|
3-(3-chloro-4-fluorophenyl)-1-(4-(5-cyanothiophen-2-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
|
C24H26ClFN4OS
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
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CP0458889
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-(2-fluoroethylamino)ethyl)urea
Show/Hide
|
C24H26Cl2FN5O
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
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CP0496548
|
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3,4-difluorophenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C27H32ClF3N4O
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
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CP0475164
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,5-difluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H36F2N4O
|
1
|
| 1 |
Ki = 4.5 nM
|
|
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CP0445739
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H36ClFN4O
|
1
|
| 1 |
Ki = 5 nM
|
|
|
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CP0427256
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(((S)-1-hydroxypropan-2-yl)(isopropyl)amino)ethyl)urea
Show/Hide
|
C29H36ClFN4O2
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0428712
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,4-difluorophenyl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C28H32F2N4O3S
|
1
|
| 1 |
Ki = 5.4 nM
|
|
|
|
CP0437068
|
3-(3-bromophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H37BrN4O
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0436379
|
N-[7-[(3-chloro-4-fluorophenyl)carbamoyl-[3-(4-methylpiperazin-1-yl)propyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]acetamide
Show/Hide
|
C27H35ClFN5O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0475165
|
3-(3-chlorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C29H37ClN4O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0425140
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)urea
Show/Hide
|
C28H32ClFN4O2
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0462328
|
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3,5-difluorophenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
|
C27H32ClF3N4O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
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CP0514382
|
1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea
Show/Hide
|
C27H28F4N4O2
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0420181
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C28H32ClFN4O3S
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
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CP0427190
|
3-(3-cyanophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C30H37N5O
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
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CP0425142
|
1-((3R,6S)-6-(3-bromophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,4-difluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
|
C28H36BrF2N3O
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
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CP0442384
|
1-[(1S,2R,5S)-5-(4-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(3-piperazin-1-ylpropyl)urea
Show/Hide
|
C28H31F4N5O
|
1
|
| 1 |
Ki = 8 nM
|
|
|
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CP0427258
|
1-(4-(5-(aminomethyl)thiophen-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
|
C24H30ClFN4OS
|
1
|
| 1 |
Ki = 8.2 nM
|
|
|
|
CP0552232
|
3-(3-chloro-4-fluorophenyl)-1-(7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
|
C26H31ClFN5O
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0439519
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)methyl)urea
Show/Hide
|
C32H38ClFN4O2
|
1
|
| 1 |
Ki = 8.7 nM
|
|
|
|
CP0486159
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((2-hydroxyethyl)(isopropyl)amino)ethyl)urea
Show/Hide
|
C28H34ClFN4O2
|
1
|
| 1 |
Ki = 8.7 nM
|
|
|
|
CP0083465
|
(R)-1-(3'-cyanobiphenyl-4-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
|
C27H24F4N4O2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0428621
|
3-(2,6-dichloropyridin-4-yl)-1-((3R,6S)-6-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C31H41Cl2N5O4S
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0208964
|
3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)-1-((1S,2R,5S)-5-phenylbicyclo[3.1.0]hexan-2-yl)urea
Show/Hide
|
C27H34ClFN4O
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0083468
|
3-(3-Chloro-4-fluoro-phenyl)-1-[(3R,6S)-6-(3-cyano-phenyl)-bicyclo[4.1.0]hept-3-yl]-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea
Show/Hide
|
C27H30ClFN4O2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0408570
|
1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[4-(2-methylpropyl)piperazin-1-yl]ethyl]urea
Show/Hide
|
C31H37F4N5O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0509343
|
3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]urea
Show/Hide
|
C28H36ClFN4O3S
|
1
|
| 1 |
Ki = 9.3 nM
|
|
|
|
CP0425144
|
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(((R)-1-hydroxypropan-2-yl)(isopropyl)amino)ethyl)urea
Show/Hide
|
C29H36ClFN4O2
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0420179
|
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-fluorophenyl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
|
C28H33FN4O3S
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
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CP0427452
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1-((3R,6S)-6-(3-(aminomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-chloro-4-fluorophenyl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
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C28H36ClFN4O3S
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1
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| 1 |
Ki = 9.9 nM
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CP0486158
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-((2-fluoroethyl)(isopropyl)amino)ethyl)urea
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C27H32Cl2FN5O
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1
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| 1 |
Ki = 10 nM
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CP0306044
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1-((1S,2R,5S)-5-(3-aminophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
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C27H35ClFN5O
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1
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| 1 |
Ki = 10 nM
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CP0379068
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)-3-(4-fluorophenyl)urea
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C29H37FN4O
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1
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| 1 |
Ki = 10.4 nM
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CP0486891
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3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)-1-(7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)urea
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C25H31ClFN5O3
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1
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| 1 |
Ki = 11 nM
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CP0377012
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclobutyl-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
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C30H30Cl2N4O
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1
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| 1 |
Ki = 11 nM
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CP0486150
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1-[1-Butyl-4-(3'-cyano-biphenyl-4-yl)-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
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C30H32Cl2N4O
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1
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| 1 |
Ki = 11 nM
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CP0427255
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((2S)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl)ethyl)urea
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C29H34ClFN4O2
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1
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| 1 |
Ki = 11 nM
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CP0525779
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(ethyl(2-hydroxyethyl)amino)ethyl)urea
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C27H32ClFN4O2
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1
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| 1 |
Ki = 11 nM
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CP0102401
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3-(3-Chloro-4-fluoro-phenyl)-1-[(1R,3R,6S)-6-(3-cyano-phenyl)-bicyclo[4.1.0]hept-3-yl]-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea
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C27H30ClFN4O2
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1
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| 1 |
Ki = 11.4 nM
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CP0495680
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((2-fluoroethyl)(isopropyl)amino)ethyl)urea
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C28H33ClF2N4O
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1
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| 1 |
Ki = 12 nM
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CP0431568
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1-[1-sec-Butyl-4-(3'-cyano-biphenyl-4-yl)-piperidin-4-ylmethyl]-3-(3,5-dichloro-phenyl)-urea
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C30H32Cl2N4O
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1
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| 1 |
Ki = 13 nM
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CP0439787
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1-(4-(2-(aminomethyl)thiazol-5-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H29ClFN5OS
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1
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| 1 |
Ki = 13 nM
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CP0445741
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-((dimethylamino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
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C31H44ClFN4O
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1
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| 1 |
Ki = 13 nM
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CP0446626
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3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-thiophen-3-yl-2-bicyclo[3.1.0]hexanyl]urea
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C25H32ClFN4OS
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1
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| 1 |
Ki = 13 nM
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CP0496562
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3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-[4-(trifluoromethoxy)phenyl]-2-bicyclo[3.1.0]hexanyl]urea
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C28H33ClF4N4O2
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1
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| 1 |
Ki = 13 nM
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CP0424365
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-((dimethylamino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
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C30H40ClFN4O3S
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1
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| 1 |
Ki = 15 nM
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CP0425138
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1-(2-(azepan-1-yl)ethyl)-3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)urea
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C29H34ClFN4O
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1
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| 1 |
Ki = 15 nM
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CP0509877
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(3-(hydroxymethyl)piperidin-1-yl)ethyl)urea
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C29H34ClFN4O2
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1
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| 1 |
Ki = 15 nM
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CP0522657
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,5-difluorophenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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C27H30F2N4O2
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1
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| 1 |
Ki = 15 nM
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CP0525780
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)urea
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C28H32ClFN4O2
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1
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| 1 |
Ki = 15 nM
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CP0552285
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(2-methylpiperidin-1-yl)ethyl)urea
Show/Hide
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C29H34ClFN4O
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1
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| 1 |
Ki = 15 nM
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CP0451810
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1-[(1R,2S,5R)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
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C26H28Cl2N4O
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1
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| 1 |
Ki = 15 nM
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CP0538087
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-chlorophenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
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C27H33Cl2FN4O
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1
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| 1 |
Ki = 15 nM
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CP0376432
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6-(3-cyano-phenyl)-bicyclo[4.1.0]hept-3-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((S)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea
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C28H30F4N4O2
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1
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| 1 |
Ki = 15.1 nM
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CP0475162
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(2-methylpyrrolidin-1-yl)ethyl)urea
Show/Hide
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C28H32ClFN4O
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1
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| 1 |
Ki = 16 nM
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CP0458892
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1-(4-(5-(aminomethyl)thiazol-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H29ClFN5OS
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1
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| 1 |
Ki = 17 nM
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CP0526231
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-(methylsulfonamidomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
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C30H42ClFN4O3S
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1
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| 1 |
Ki = 18 nM
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CP0408571
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-1-(2-pyrrolidin-1-ylethyl)urea
Show/Hide
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C26H28ClFN4O
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1
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| 1 |
Ki = 18 nM
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CP0379065
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,4-difluorophenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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C27H30F2N4O2
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1
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| 1 |
Ki = 20 nM
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CP0525778
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-fluorophenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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C27H31FN4O2
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1
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| 1 |
Ki = 20 nM
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CP0427447
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,4-difluorophenyl)-1-((1-(ethylsulfonyl)piperidin-4-yl)methyl)urea
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C29H34F2N4O3S
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1
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| 1 |
Ki = 21 nM
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CP0427450
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
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C33H46ClFN4O2
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1
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| 1 |
Ki = 21 nM
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CP0427526
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(4-hydroxypiperidin-1-yl)ethyl)urea
Show/Hide
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C28H32ClFN4O2
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1
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| 1 |
Ki = 22 nM
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CP0425141
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1-(2-(3-acetamidopyrrolidin-1-yl)ethyl)-3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
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C29H33ClFN5O2
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1
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| 1 |
Ki = 23 nM
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CP0444781
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N-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-phenylbenzamide
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C26H28N2O3
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1
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| 1 |
Ki = 25 nM
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CP0432851
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-((1-(methylsulfonyl)piperidin-4-yl)methyl)urea
Show/Hide
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C29H32F4N4O3S
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1
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| 1 |
Ki = 26 nM
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CP0552286
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3-(3-chlorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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C27H31ClN4O2
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1
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| 1 |
Ki = 27 nM
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CP0522658
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-((E)-(ethoxyimino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
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C31H42ClFN4O2
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1
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| 1 |
Ki = 29 nM
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CP0495932
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3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-[3-(trifluoromethoxy)phenyl]-2-bicyclo[3.1.0]hexanyl]urea
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C28H33ClF4N4O2
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1
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| 1 |
Ki = 29 nM
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CP0503350
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3-(3-chloro-4-fluorophenyl)-1-(4-(pyridin-3-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C24H28ClFN4O
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1
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| 1 |
Ki = 30 nM
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CP0538085
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1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(4-methylpiperazin-1-yl)ethyl]urea
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C28H31F4N5O
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1
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| 1 |
Ki = 30 nM
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CP0427451
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1-((3R,6S)-6-(3-(acetamidomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
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C31H42ClFN4O2
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1
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| 1 |
Ki = 31 nM
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CP0445742
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1-(4-(5-acetylthiophen-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C25H29ClFN3O2S
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1
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| 1 |
Ki = 31 nM
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CP0496561
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-methylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C28H36ClFN4O
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1
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| 1 |
Ki = 33 nM
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CP0424351
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3-(3-bromophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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C27H31BrN4O2
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1
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| 1 |
Ki = 34 nM
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CP0427448
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methyl 3-[(1S,4R)-4-[(3,4-difluorophenyl)carbamoyl-[2-[di(propan-2-yl)amino]ethyl]amino]-1-bicyclo[4.1.0]heptanyl]benzoate
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C30H39F2N3O3
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1
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| 1 |
Ki = 34 nM
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CP0427454
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-((diethylamino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
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C33H48ClFN4O
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1
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| 1 |
Ki = 46 nM
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CP0427453
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-(hydroxymethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
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C29H39ClFN3O2
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1
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| 1 |
Ki = 48 nM
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CP0528615
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-fluoro-4-methylphenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C28H33FN4O2
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1
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| 1 |
Ki = 48 nM
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CP0526232
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3-(3-chloro-4-fluorophenyl)-1-(4-(5-formylfuran-2-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C24H27ClFN3O3
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1
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| 1 |
Ki = 51 nM
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CP0427525
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-morpholinoethyl)urea
Show/Hide
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C27H30ClFN4O2
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1
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| 1 |
Ki = 53 nM
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CP0424350
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(4-fluorophenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C27H31FN4O2
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1
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| 1 |
Ki = 54 nM
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CP0424364
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3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-((4-methylpiperazin-1-yl)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
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C34H49ClFN5O
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1
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| 1 |
Ki = 54 nM
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CP0458893
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3-(3-chloro-4-fluorophenyl)-1-(4-(2-cyanothiazol-5-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H25ClFN5OS
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1
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| 1 |
Ki = 57 nM
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CP0475163
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)-3-(3-nitrophenyl)urea
Show/Hide
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C27H31N5O4
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1
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| 1 |
Ki = 60 nM
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CP0542433
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N-[7-[(3-chloro-4-fluorophenyl)carbamoyl-[3-(4-methylpiperazin-1-yl)propyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]-2-methylpropanamide
Show/Hide
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C29H39ClFN5O2
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1
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| 1 |
Ki = 61 nM
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CP0547184
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4-Benzyl-N-[4-(2-diisopropylamino-ethoxy)-3-methoxy-phenyl]-benzamide
Show/Hide
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C29H36N2O3
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1
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| 1 |
Ki = 79 nM
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CP0427257
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(1-(methylsulfonyl)piperidin-4-yl)ethyl)urea
Show/Hide
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C30H34F4N4O3S
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1
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| 1 |
Ki = 80 nM
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CP0452733
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N-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-phenoxybenzamide
Show/Hide
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C26H28N2O4
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1
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| 1 |
Ki = 82 nM
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CP0499271
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4-[3-(3,5-Dichloro-phenyl)-ureidomethyl]-4-(4-pyridin-3-yl-phenyl)-piperidine-1-sulfonic acid dimethylamide
Show/Hide
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C26H29Cl2N5O3S
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1
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| 1 |
Ki = 84 nM
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CP0424367
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3-(3-chloro-4-fluorophenyl)-1-(4-(5-methylthiophen-2-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C24H29ClFN3OS
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1
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| 1 |
Ki = 85 nM
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CP0510970
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3-(3-chloro-4-fluorophenyl)-1-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
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C26H34ClFN4O2
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1
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| 1 |
Ki = 92 nM
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CP0379067
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3-(3-cyanophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C28H31N5O2
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1
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| 1 |
Ki = 92 nM
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CP0427186
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3-(3,4-difluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-phenylbicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
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C28H37F2N3O
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1
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| 1 |
Ki = 92 nM
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CP0436912
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3-(3-chloro-4-fluorophenyl)-1-[7-(methanesulfonamido)-1,2,3,4-tetrahydronaphthalen-2-yl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C26H35ClFN5O3S
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1
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| 1 |
Ki = 96 nM
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CP0390959
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1-(2-Fluoro-phenyl)-3-[1-(1-methyl-1H-benzoimidazol-2-ylmethyl)-4-(4-pyridin-3-yl-phenyl)-piperidin-4-ylmethyl]-urea
Show/Hide
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C33H33FN6O
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1
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| 1 |
Ki = 98 nM
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CP0916304
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N-((R)-1-{4-[3-(3-Chloro-4-fluoro-phenyl)-1-(3''-cyano-biphenyl-4-yl)-ureido]-butyl}-pyrrolidin-3-yl)-acetamide
Show/Hide
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C30H31ClFN5O2
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1
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| 1 |
Ki < 100 nM
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CP0467224
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1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-3-(4-phenoxyphenyl)urea
Show/Hide
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C26H29N3O4
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1
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| 1 |
Ki = 101 nM
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CP0424363
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3-(3-chloro-4-fluorophenyl)-1-(4-(furan-2-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H27ClFN3O2
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1
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| 1 |
Ki = 117 nM
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CP0427523
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)-3-phenylurea
Show/Hide
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C27H32N4O2
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1
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| 1 |
Ki = 132 nM
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CP0379064
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3-(benzo[d][1,3]dioxol-5-yl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C28H32N4O4
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1
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| 1 |
Ki = 134 nM
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CP0475871
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1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-3-(2,5-dichloro-phenyl)-urea
Show/Hide
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C27H26Cl2N4O
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1
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| 1 |
Ki = 140 nM
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CP0427527
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1-((3R,6S)-6-(3-carbamoylphenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)urea
Show/Hide
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C29H38ClFN4O2
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1
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| 1 |
Ki = 142 nM
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CP0458897
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3-(3-chloro-4-fluorophenyl)-1-(4-(pyrimidin-5-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H27ClFN5O
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1
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| 1 |
Ki = 147 nM
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CP0538262
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3,5-Dichloro-N-[4-(3'-cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-benzamide
Show/Hide
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C27H25Cl2N3O
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1
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| 1 |
Ki = 155 nM
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CP0485283
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1-(3-chloro-4-fluorophenyl)-3-{7-[(ethylcarbamoyl)amino]-1,2,3,4-tetrahydronaphthalen-2-yl}-3-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C28H38ClFN6O2
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1
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| 1 |
Ki = 160 nM
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CP0538083
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3-(3-chloro-4-fluorophenyl)-1-[(1R,3R)-3-(3-cyanophenyl)cyclopentyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C27H33ClFN5O
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1
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| 1 |
Ki = 161 nM
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CP0733873
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1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C28H29N3O5
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1
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| 1 |
Ki = 164 nM
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CP0376965
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N-[[4-[4-(3-cyanophenyl)phenyl]-1-methylpiperidin-4-yl]methyl]-2-(3,5-dichlorophenyl)acetamide
Show/Hide
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C28H27Cl2N3O
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1
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| 1 |
Ki = 164 nM
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CP0524292
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(Z)-5-(4-((3-hydroxypyrrolidin-1-yl)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C27H25N3O4
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1
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| 1 |
Ki = 176 nM
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CP0436911
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1-(6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
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C25H31BrClFN4O
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1
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| 1 |
Ki = 180 nM
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CP0437078
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-((1-(methylcarbamoyl)piperidin-4-yl)methyl)urea
Show/Hide
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C30H33F4N5O2
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1
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| 1 |
Ki = 181 nM
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CP0436376
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3-(3-chloro-4-fluorophenyl)-1-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
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C26H34ClFN4O2
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1
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| 1 |
Ki = 190 nM
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CP0486161
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-3-yl)methyl)urea
Show/Hide
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C28H32ClFN4O3S
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1
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| 1 |
Ki = 211 nM
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CP0144422
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(Z)-5-(4-(pyrrolidin-1-ylmethyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C27H25N3O3
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1
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| 1 |
Ki = 220 nM
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CP0552214
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1-(7-amino-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
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C25H33ClFN5O
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1
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| 1 |
Ki = 260 nM
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CP0485153
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1-biphenyl-4-yl-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea
Show/Hide
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C26H29N3O3
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1
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| 1 |
Ki = 260 nM
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CP0540191
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3,5-Dichloro-N-[4-(3'-cyano-biphenyl-4-yl)-1-methyl-piperidin-4-ylmethyl]-benzenesulfonamide
Show/Hide
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C26H25Cl2N3O2S
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1
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| 1 |
Ki = 281 nM
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CP0428710
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(methylsulfonyl)piperidin-2-yl)methyl)urea
Show/Hide
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C28H32ClFN4O3S
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1
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| 1 |
Ki = 295 nM
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CP0445731
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1-((1-acetylpiperidin-4-yl)methyl)-3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)urea
Show/Hide
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C29H32ClFN4O2
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1
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| 1 |
Ki = 312 nM
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CP0553191
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1-(4-(benzofuran-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C27H29ClFN3O2
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1
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| 1 |
Ki = 316 nM
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CP0453667
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3-(3-chloro-4-fluorophenyl)-1-(6-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
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C26H31ClFN5O
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1
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| 1 |
Ki = 340 nM
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CP0452730
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(Z)-5-(4-((dimethylamino)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C25H23N3O3
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1
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| 1 |
Ki = 341 nM
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CP0444763
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(Z)-5-(4-(azepan-1-ylmethyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C29H29N3O3
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1
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| 1 |
Ki = 357 nM
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CP0888727
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3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C28H29N3O5
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1
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| 1 |
Ki = 365 nM
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CP0525777
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)-3-(3-methoxyphenyl)urea
Show/Hide
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C28H34N4O3
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1
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| 1 |
Ki = 373 nM
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CP0453666
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3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)-1-(1,2,3,4-tetrahydronaphthalen-2-yl)urea
Show/Hide
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C25H32ClFN4O
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1
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| 1 |
Ki = 380 nM
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CP0408572
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-[3-(methanesulfonamido)phenyl]-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C28H37ClFN5O3S
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1
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| 1 |
Ki = 394 nM
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CP0955980
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3-biphenyl-4-yl-1-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazolidine-2,4-dione
Show/Hide
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C28H29N3O4
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1
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| 1 |
Ki = 415 nM
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CP0390913
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1-[1-Benzenesulfonyl-4-(4-pyridin-3-yl-phenyl)-piperidin-4-ylmethyl]-3-(2-fluoro-phenyl)-urea
Show/Hide
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C30H29FN4O3S
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1
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| 1 |
Ki = 460 nM
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CP0379063
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,5-dimethylphenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C29H36N4O2
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1
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| 1 |
Ki = 539 nM
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CP0428711
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3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(((S)-1-(methylsulfonyl)pyrrolidin-2-yl)methyl)urea
Show/Hide
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C27H30ClFN4O3S
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1
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| 1 |
Ki = 559 nM
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CP0501988
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1-[3-(3-cyanophenyl)cyclopent-2-en-1-yl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
Show/Hide
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C25H26Cl2N4O
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1
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| 1 |
Ki = 605 nM
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CP0427449
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3-(3-chloro-4-fluorophenyl)-1-(4-(2-((dimethylamino)methyl)thiazol-5-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C25H33ClFN5OS
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1
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| 1 |
Ki = 648 nM
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CP0464775
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(Z)-5-(4-((2-(dimethylamino)ethylamino)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C27H28N4O3
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1
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| 1 |
Ki = 707 nM
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CP0538086
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3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-(3-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]urea
Show/Hide
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C28H36ClFN4O3S
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1
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| 1 |
Ki = 727 nM
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CP0432850
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4-[[[[(3-chloro-4-fluorophenyl)amino]carbonyl][(trans-5-[4-(methylsulfonyl)phenyl]bicyclo[3.1.0]hex-2-yl]amino]methyl]-1-(methylsulfonyl)piperidine
Show/Hide
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C27H33ClFN3O5S2
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1
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| 1 |
Ki = 974 nM
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CP0452731
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N-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-(4-phenoxyphenyl)-1,3-thiazol-2-amine
Show/Hide
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C28H29N3O3S
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1
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| 1 |
Ki = 1000 nM
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CP0452732
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1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-3-(4-phenoxyphenyl)thiourea
Show/Hide
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C26H29N3O3S
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1
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| 1 |
Ki = 1090 nM
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CP0911660
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1-(3,5-Dichloro-phenyl)-3-{4-[4-(3a,7a-dihydro-1H-indol-4-yl)-phenyl]-1-methyl-piperidin-4-ylmethyl}-urea
Show/Hide
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C28H28Cl2N4O
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1
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| 1 |
Ki = 1188 nM
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CP0453668
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3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)-1-(7-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-2-yl)urea
Show/Hide
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C26H34ClFN4O3S
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1
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| 1 |
Ki = 1300 nM
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CP0514385
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(2-oxopyrrolidin-1-yl)propyl]urea
Show/Hide
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C27H31ClFN3O4S
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1
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| 1 |
Ki = 1615 nM
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CP0457923
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N,N-bis[(4-methylphenyl)sulfonylmethyl]hexan-1-amine
Show/Hide
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C22H31NO4S2
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1
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| 1 |
Ki = 1700 nM
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CP0379066
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2-fluorophenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C27H31FN4O2
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1
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| 1 |
Ki = 1884 nM
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CP0420182
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1-(4-(1H-pyrrol-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
Show/Hide
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C23H28ClFN4O
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1
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| 1 |
Ki = 1969 nM
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CP0524293
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(Z)-5-(4-((4-acetylpiperazin-1-yl)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C29H28N4O4
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1
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| 1 |
Ki = 2060 nM
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CP0495930
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3-(3-chloro-4-fluorophenyl)-1-[(1S,3R)-3-(3-cyanophenyl)cyclopentyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
Show/Hide
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C27H33ClFN5O
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1
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| 1 |
Ki = 2190 nM
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CP0444407
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1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-cyclohexyl-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
Show/Hide
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C27H38N4O2
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1
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| 1 |
Ki = 2213 nM
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CP0436377
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7-(3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)ureido)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
Show/Hide
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C27H37ClFN5O3S
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1
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| 1 |
Ki = 3000 nM
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CP0453669
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7-(3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)ureido)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
Show/Hide
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C26H35ClFN5O3S
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1
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| 1 |
Ki = 3000 nM
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CP0454167
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2-phenyl-N,N-bis(o-tolylthiomethyl)ethanamine
Show/Hide
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C24H27NS2
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1
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| 1 |
Ki = 7500 nM
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CP0524213
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N,N-bis[(4-methylphenyl)sulfonylmethyl]-1-phenylmethanamine
Show/Hide
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C23H25NO4S2
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1
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| 1 |
Ki = 7500 nM
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CP0528046
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6-(((3-chlorobenzyl)(methyl)amino)methyl)-N2-o-tolyl-1,3,5-triazine-2,4-diamine
Show/Hide
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C19H21ClN6
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1
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| 1 |
Ki = 7800 nM
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CP0513717
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2-(dimethylamino)ethyl 4-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoate
Show/Hide
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C19H24N2O4S2
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1
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| 1 |
Ki = 8100 nM
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CP0427665
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4-methoxy-benzoic acid 2-diethylaminomethyl-4-(1,1-dioxo-1H-1lambda6-benzo[d]isothiazol-3-ylamino)-phenyl ester
Show/Hide
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C26H27N3O5S
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1
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| 1 |
Ki = 11300 nM
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CP0454168
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3-[2-(4-bromophenyl)imidazo[1,2-a]benzimidazol-3-yl]-N,N-diethylpropan-1-amine
Show/Hide
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C22H25BrN4
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1
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| 1 |
Ki = 11900 nM
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CP0513692
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N-[3-[benzyl(propan-2-yl)amino]propyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide
Show/Hide
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C21H27N3OS
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1
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| 1 |
Ki = 20900 nM
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CP0918562
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4-{1-[(S)-4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylmethyl)-benzoylamino]-propyl}-benzoic acid methyl ester
Show/Hide
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C32H36N2O5
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1
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| 1 |
Ki <= 1500 nM
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CP0514367
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3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-(2-pyridin-2-ylethyl)urea
Show/Hide
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C27H27ClFN3O3S
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1
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| 1 |
Ki > 3000 nM
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CP0434268
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(Z)-5-(4-((4-phenylpiperazin-1-yl)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C33H30N4O3
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1
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| 1 |
Ki > 5000 nM
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CP0444764
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(Z)-5-(4-(piperidin-1-ylmethyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C28H27N3O3
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1
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| 1 |
Ki > 5000 nM
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CP0467223
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(Z)-5-(4-(morpholinomethyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C27H25N3O4
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1
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| 1 |
Ki > 5000 nM
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CP0490434
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(Z)-5-(4-((cyclopentylamino)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C28H27N3O3
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1
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| 1 |
Ki > 5000 nM
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CP0490437
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(Z)-5-(4-((4-benzylpiperazin-1-yl)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C34H32N4O3
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1
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| 1 |
Ki > 5000 nM
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CP0533056
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(Z)-5-(4-((benzylamino)methyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione
Show/Hide
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C30H25N3O3
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1
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| 1 |
Ki > 5000 nM
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CP0918467
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1-biphenyl-4-yl-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazolidine-2,4-dione
Show/Hide
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C28H29N3O4
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1
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| 1 |
Ki > 5000 nM
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