General Information of the Compound
Compound ID
CP0441370
Compound Name
N-[3-[1-[3-[4-[4-(dimethylamino)phenyl]-1-oxophthalazin-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
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Structure
Formula
C32H37N5O2
Molecular Weight
523.681
Canonical SMILES
CN(C)c1ccc(cc1)-c1nn(CCCN2CCC(CC2)c2cccc(NC(C)=O)c2)c(=O)c2ccccc12
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InChI
InChI=1S/C32H37N5O2/c1-23(38)33-27-9-6-8-26(22-27)24-16-20-36(21-17-24)18-7-19-37-32(39)30-11-5-4-10-29(30)31(34-37)25-12-14-28(15-13-25)35(2)3/h4-6,8-15,22,24H,7,16-21H2,1-3H3,(H,33,38)
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InChIKey
QBHRICSAYBDLRA-UHFFFAOYSA-N
Physicochemical Property
logP
5.3576
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
70.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57394273
SID: 152140346
ChEMBL ID
CHEMBL1934831
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 423 nM
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