General Information of the Compound
Compound ID
CP0424367
Compound Name
3-(3-chloro-4-fluorophenyl)-1-(4-(5-methylthiophen-2-yl)cyclohex-3-enyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
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Structure
Formula
C24H29ClFN3OS
Molecular Weight
462.034
Canonical SMILES
Cc1ccc(s1)C1=CCC(CC1)N(CCN1CCCC1)C(=O)Nc1ccc(F)c(Cl)c1
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InChI
InChI=1S/C24H29ClFN3OS/c1-17-4-11-23(31-17)18-5-8-20(9-6-18)29(15-14-28-12-2-3-13-28)24(30)27-19-7-10-22(26)21(25)16-19/h4-5,7,10-11,16,20H,2-3,6,8-9,12-15H2,1H3,(H,27,30)
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InChIKey
BWGKUHVGLLNUIX-UHFFFAOYSA-N
Physicochemical Property
logP
6.41482
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424267
ChEMBL ID
CHEMBL229408
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 85 nM
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