General Information of the Compound
Compound ID
CP0439519
Compound Name
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-((1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)methyl)urea
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Structure
Formula
C32H38ClFN4O2
Molecular Weight
565.133
Canonical SMILES
Fc1ccc(NC(=O)N(CC2CCN(CC2)C2CCOCC2)[C@@H]2CC[C@@]3(CC3C2)c2cccc(c2)C#N)cc1Cl
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InChI
InChI=1S/C32H38ClFN4O2/c33-29-18-26(4-5-30(29)34)36-31(39)38(21-22-7-12-37(13-8-22)27-9-14-40-15-10-27)28-6-11-32(19-25(32)17-28)24-3-1-2-23(16-24)20-35/h1-5,16,18,22,25,27-28H,6-15,17,19,21H2,(H,36,39)/t25?,28-,32-/m1/s1
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InChIKey
DBKHVWOXHXKVIF-ZXVOXEBXSA-N
Physicochemical Property
logP
6.58608
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
68.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424224
ChEMBL ID
CHEMBL229285
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8.7 nM
   TI
   LI
   LO
   TS