General Information of the Compound
Compound ID
CP0472692
Compound Name
4-phenyl-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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Structure
Formula
C28H28N2O
Molecular Weight
408.545
Canonical SMILES
O=C(Nc1ccc2C=C(CN3CCCC3)CCc2c1)c1ccc(cc1)-c1ccccc1
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InChI
InChI=1S/C28H28N2O/c31-28(24-12-10-23(11-13-24)22-6-2-1-3-7-22)29-27-15-14-25-18-21(8-9-26(25)19-27)20-30-16-4-5-17-30/h1-3,6-7,10-15,18-19H,4-5,8-9,16-17,20H2,(H,29,31)
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InChIKey
QQNJJXBJUFOPQJ-UHFFFAOYSA-N
Physicochemical Property
logP
6.0313
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 21940008
ChEMBL ID
CHEMBL1818809
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 6.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 17 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS