General Information of the Protein
Protein ID
PT01388
Protein Name
Melanin-concentrating hormone receptor 1
Secondarily
Protein Name
G-protein coupled receptor 24
MCH-1R
SLC-1
Somatostatin receptor-like protein
Gene Name
MCHR1
Secondarily
Gene Name
Gpr24
Slc1
Sequence
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
MCH receptor
Function
Receptor for melanin-concentrating hormone, coupled to G proteins that inhibit adenylyl cyclase.
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Uniprot ID
Primary ID:
P97639

Secondarily ID:
A0A140TAD3
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000832 , CHO-K1/Gqi5
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0376182
 Compound Info 
1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)phenyl)-3-phenylurea
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C28H32N4O3
  1
1
Ki = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0159718
 Compound Info 
N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H30F2N2O2
  2
1 IC50 = 1.8 nM
2 Ki = 1.8 nM
CP0344964
 Compound Info 
(R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3-yl)-2-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyridazin-7(6H)-one
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C23H20F3N5OS
  1
1 IC50 = 7.7 nM
CP0045374
 Compound Info 
(S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3-yl)phthalazin-1(2H)-one
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C24H22ClN5O
  1
1 IC50 = 8.5 nM
CP0254955
 Compound Info 
1-(6-{13-[4-(trifluoromethyl)phenyl]tridecanamido}quinolin-2-yl)-1-azabicyclo[2.2.2]octan-1-ylium
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C36H47F3N3O+
  1
1 IC50 = 13 nM
CP0051323
 Compound Info 
(S)-3-{3-[4-(3-Acetylamino-phenyl)-piperidin-1-yl]-propylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
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C31H37F2N5O6
  2
1 Ki = 0.25 nM
2 Ki = 2 nM
CP0340539
 Compound Info 
N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]piperidin-4-yl]-4-methylphenyl]-2-methylpropanamide
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C29H32F2N2O2
  1
1 Ki = 2.2 nM
CP0157382
 Compound Info 
N-[3-[1-[4-(4-chlorophenyl)-4-oxobutyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C25H31ClN2O2
  1
1 Ki = 5 nM
CP0159752
 Compound Info 
N-[3-[1-[[4-(4-chlorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H31ClN2O2
  1
1 Ki = 5.3 nM
CP0159747
 Compound Info 
N-[3-[1-[[4-(3,4-dichlorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H30Cl2N2O2
  1
1 Ki = 8.2 nM
CP0162179
 Compound Info 
2-methyl-N-{3-[1-(4-phenoxybenzyl)-4-piperidinyl]phenyl}-propanamide
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C28H32N2O2
  1
1 Ki = 10 nM
CP0179101
 Compound Info 
N-[3-[1-[[3-(3,4-dichlorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H30Cl2N2O2
  1
1 Ki = 18 nM
CP0256127
 Compound Info 
N-[3-[1-[[3-(4-chlorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H31ClN2O2
  1
1 Ki = 23 nM
CP0036042
 Compound Info 
N-[5-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]piperidin-4-yl]-2-methylphenyl]-2-methylpropanamide
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C29H32F2N2O2
  1
1 Ki = 27 nM
CP0159812
 Compound Info 
N-[3-[1-[[4-(4-methoxyphenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C29H34N2O3
  1
1 Ki = 35 nM
CP0036109
 Compound Info 
2-methyl-N-[3-(1-{3-[3-(trifluoromethyl)phenoxy]benzyl}-4-piperidinyl)phenyl]-propanamide
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C29H31F3N2O2
  1
1 Ki = 65 nM
CP0051335
 Compound Info 
N-[3-[1-[4-(4-chlorophenyl)-4-oxobutyl]piperidin-4-yl]phenyl]acetamide
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C23H27ClN2O2
  1
1 Ki = 70 nM
CP0051328
 Compound Info 
N-[3-[1-[4-(3,4-dimethylphenyl)-4-oxobutyl]piperidin-4-yl]phenyl]acetamide
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C25H32N2O2
  1
1 Ki = 100 nM
CP0174364
 Compound Info 
N-[3-[1-[[3-(3,5-dichlorophenoxy)phenyl]methyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C28H30Cl2N2O2
  1
1 Ki = 140 nM
CP0051326
 Compound Info 
N-[3-[1-(4-oxo-4-phenylbutyl)piperidin-4-yl]phenyl]acetamide
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C23H28N2O2
  1
1 Ki = 350 nM
CP0159814
 Compound Info 
N-[3-[1-[4-(4-methylphenyl)-4-oxobutyl]piperidin-4-yl]phenyl]acetamide
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C24H30N2O2
  1
1 Ki = 360 nM
CP0174365
 Compound Info 
N-[3-[1-[4-oxo-4-(4-phenoxyphenyl)butyl]piperidin-4-yl]phenyl]acetamide
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C29H32N2O3
  1
1 Ki = 490 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01027 Melanin-concentrating hormone receptor 1 Homo sapiens, Human
 Protein Info 
PT03304 Melanin-concentrating hormone receptor 1 Mus musculus, Mouse
 Protein Info