General Information of the Protein
| Protein ID |
PT03304
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| Protein Name |
Melanin-concentrating hormone receptor 1
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| Secondarily Protein Name |
G-protein coupled receptor 24
MCH-1R
SLC-1
Somatostatin receptor-like protein
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| Gene Name |
MCHR1
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| Secondarily Gene Name |
Gpr24
Slc1
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| Sequence |
MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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MCH receptor
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| Function |
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
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| Uniprot ID |
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| Subcellular Location |
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000832 , CHO-K1/Gqi5
| Compound ID | Compound Name | Compound Formula | |
| CP0376182 |
1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)phenyl)-3-phenylurea
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C28H32N4O3
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1 |
| 1 |
Ki = 14 nM
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TI
LI
LO
TS
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Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000016 , IMR-32
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT01027 | Melanin-concentrating hormone receptor 1 | Homo sapiens, Human | |
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| PT01388 | Melanin-concentrating hormone receptor 1 | Rattus norvegicus, Rat | |