General Information of the Compound
Compound ID
CP0442848
Compound Name
6-(4-chlorophenyl)-3-[2-(1-pyrrolidinylmethyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]thieno[3,2-d]pyrimidin-4 (3H)-one
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Structure
Formula
C25H23ClN4O2S
Molecular Weight
479.005
Canonical SMILES
Clc1ccc(cc1)-c1cc2ncn(-c3ccc4OC(CN5CCCC5)CNc4c3)c(=O)c2s1
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InChI
InChI=1S/C25H23ClN4O2S/c26-17-5-3-16(4-6-17)23-12-21-24(33-23)25(31)30(15-28-21)18-7-8-22-20(11-18)27-13-19(32-22)14-29-9-1-2-10-29/h3-8,11-12,15,19,27H,1-2,9-10,13-14H2
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InChIKey
HYJDZUVIJDAGNE-UHFFFAOYSA-N
Physicochemical Property
logP
5.0363
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
59.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11995347
SID: 17494465
ChEMBL ID
CHEMBL215286
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.3 nM
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