General Information of the Compound
Compound ID
CP0452731
Compound Name
N-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-(4-phenoxyphenyl)-1,3-thiazol-2-amine
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Structure
Formula
C28H29N3O3S
Molecular Weight
487.625
Canonical SMILES
COc1cc(Nc2nc(cs2)-c2ccc(Oc3ccccc3)cc2)ccc1OCCN1CCCC1
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InChI
InChI=1S/C28H29N3O3S/c1-32-27-19-22(11-14-26(27)33-18-17-31-15-5-6-16-31)29-28-30-25(20-35-28)21-9-12-24(13-10-21)34-23-7-3-2-4-8-23/h2-4,7-14,19-20H,5-6,15-18H2,1H3,(H,29,30)
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InChIKey
GCGJCQDSXWRBSQ-UHFFFAOYSA-N
Physicochemical Property
logP
6.8292
Rotatable Bonds
10
Heavy Atom Count
35
Polar Areas
55.85
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44440593
ChEMBL ID
CHEMBL394311
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1000 nM
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