General Information of the Compound
Compound ID
CP0507861
Compound Name
2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(2-oxopiperazin-1-yl)acetamide
    Show/Hide
Structure
Formula
C29H35F3N4O3
Molecular Weight
544.618
Canonical SMILES
CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCNCC1=O)c1ccc(F)c(F)c1
    Show/Hide
InChI
InChI=1S/C29H35F3N4O3/c1-2-35(28(38)27(36-15-10-33-18-26(36)37)20-5-7-24(31)25(32)16-20)12-3-11-34-13-8-29(9-14-34)23-17-22(30)6-4-21(23)19-39-29/h4-7,16-17,27,33H,2-3,8-15,18-19H2,1H3
    Show/Hide
InChIKey
JGOSZIHAFPICES-UHFFFAOYSA-N
Physicochemical Property
logP
3.3369
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
65.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45273335
ChEMBL ID
CHEMBL558305
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.87 nM
   TI
   LI
   LO
   TS