General Information of the Compound
Compound ID
CP0379063
Compound Name
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(3,5-dimethylphenyl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea
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Structure
Formula
C29H36N4O2
Molecular Weight
472.633
Canonical SMILES
Cc1cc(C)cc(NC(=O)N(CCN2CC[C@@H](O)C2)[C@@H]2CC[C@@]3(CC3C2)c2cccc(c2)C#N)c1
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InChI
InChI=1S/C29H36N4O2/c1-20-12-21(2)14-25(13-20)31-28(35)33(11-10-32-9-7-27(34)19-32)26-6-8-29(17-24(29)16-26)23-5-3-4-22(15-23)18-30/h3-5,12-15,24,26-27,34H,6-11,16-17,19H2,1-2H3,(H,31,35)/t24?,26-,27-,29-/m1/s1
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InChIKey
QHDWECHIZQEQSB-YZUVOLLESA-N
Physicochemical Property
logP
4.58602
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
79.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424175
ChEMBL ID
CHEMBL229557
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 539 nM
   TI
   LI
   LO
   TS