General Information of the Compound
Compound ID
CP0427454
Compound Name
3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-((diethylamino)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-(diisopropylamino)ethyl)urea
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Structure
Formula
C33H48ClFN4O
Molecular Weight
571.225
Canonical SMILES
CCN(CC)Cc1cccc(c1)[C@@]12CC1C[C@@H](CC2)N(CCN(C(C)C)C(C)C)C(=O)Nc1ccc(F)c(Cl)c1
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InChI
InChI=1S/C33H48ClFN4O/c1-7-37(8-2)22-25-10-9-11-26(18-25)33-15-14-29(19-27(33)21-33)39(17-16-38(23(3)4)24(5)6)32(40)36-28-12-13-31(35)30(34)20-28/h9-13,18,20,23-24,27,29H,7-8,14-17,19,21-22H2,1-6H3,(H,36,40)/t27?,29-,33-/m1/s1
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InChIKey
RYKUCGZOIHVSPY-JNEWTYKWSA-N
Physicochemical Property
logP
7.784
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
38.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424252
ChEMBL ID
CHEMBL375466
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 46 nM
   TI
   LI
   LO
   TS