General Information of the Compound
Compound ID
CP0514367
Compound Name
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-(2-pyridin-2-ylethyl)urea
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Structure
Formula
C27H27ClFN3O3S
Molecular Weight
528.049
Canonical SMILES
CS(=O)(=O)c1ccc(cc1)[C@@]12C[C@@H]1[C@@H](CC2)N(CCc1ccccn1)C(=O)Nc1ccc(F)c(Cl)c1
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InChI
InChI=1S/C27H27ClFN3O3S/c1-36(34,35)21-8-5-18(6-9-21)27-13-11-25(22(27)17-27)32(15-12-19-4-2-3-14-30-19)26(33)31-20-7-10-24(29)23(28)16-20/h2-10,14,16,22,25H,11-13,15,17H2,1H3,(H,31,33)/t22-,25-,27-/m1/s1
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InChIKey
ORLUXGKGJLFCBT-AVPJRLCVSA-N
Physicochemical Property
logP
5.4745
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
79.37
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11519341
SID: 16621254
ChEMBL ID
CHEMBL380718
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 3000 nM
   TI
   LI
   LO
   TS