General Information of the Compound
Compound ID
CP0452271
Compound Name
4-(4-fluorophenyl)-N-[8-methoxy-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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Structure
Formula
C28H26FN3O2
Molecular Weight
455.533
Canonical SMILES
COc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12
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InChI
InChI=1S/C28H26FN3O2/c1-34-27-25(13-10-23-16-19(17-30-26(23)27)18-32-14-2-3-15-32)31-28(33)22-6-4-20(5-7-22)21-8-11-24(29)12-9-21/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33)
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InChIKey
VQLSRZQYBLRCNJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.8976
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
54.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18436095
ChEMBL ID
CHEMBL2031728
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 110 nM
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