General Information of the Compound
Compound ID
CP0451829
Compound Name
2-(2,4-Dichloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-propionamide
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Structure
Formula
C25H28Cl2N4O2
Molecular Weight
487.431
Canonical SMILES
CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)C(C)Oc3ccc(Cl)cc3Cl)ccc2n1
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InChI
InChI=1S/C25H28Cl2N4O2/c1-4-30-9-11-31(12-10-30)24-13-16(2)20-15-19(6-7-22(20)29-24)28-25(32)17(3)33-23-8-5-18(26)14-21(23)27/h5-8,13-15,17H,4,9-12H2,1-3H3,(H,28,32)
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InChIKey
WACZZEOIDRYYDD-UHFFFAOYSA-N
Physicochemical Property
logP
5.39792
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
57.7
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22421749
ChEMBL ID
CHEMBL184860
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 230 nM
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