General Information of the Compound
Compound ID
CP0499067
Compound Name
4-(cyclopropylmethoxy)-N-[3-[1-(2-hydroxyethylamino)ethyl]-8-methylquinolin-7-yl]benzamide
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Structure
Formula
C25H29N3O3
Molecular Weight
419.525
Canonical SMILES
CC(NCCO)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1
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InChI
InChI=1S/C25H29N3O3/c1-16-23(10-7-20-13-21(14-27-24(16)20)17(2)26-11-12-29)28-25(30)19-5-8-22(9-6-19)31-15-18-3-4-18/h5-10,13-14,17-18,26,29H,3-4,11-12,15H2,1-2H3,(H,28,30)
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InChIKey
LGVJSFVTVWXIFE-UHFFFAOYSA-N
Physicochemical Property
logP
4.22722
Rotatable Bonds
9
Heavy Atom Count
31
Polar Areas
83.48
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57522950
SID: 137280539
ChEMBL ID
CHEMBL2059425
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS