General Information of the Compound
Compound ID
CP0499923
Compound Name
6-(4-chlorophenyl)-3-{2-[(4-phenyl-1-piperidinyl)methyl]-6-quinolinyl}thieno[3,2-d]pyrimidin-4(3H)-one
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Structure
Formula
C33H27ClN4OS
Molecular Weight
563.126
Canonical SMILES
Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCC(CC5)c5ccccc5)ccc4c3)c(=O)c2s1
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InChI
InChI=1S/C33H27ClN4OS/c34-26-9-6-24(7-10-26)31-19-30-32(40-31)33(39)38(21-35-30)28-12-13-29-25(18-28)8-11-27(36-29)20-37-16-14-23(15-17-37)22-4-2-1-3-5-22/h1-13,18-19,21,23H,14-17,20H2
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InChIKey
ODMRZHCWTPHENJ-UHFFFAOYSA-N
Physicochemical Property
logP
7.6954
Rotatable Bonds
5
Heavy Atom Count
40
Polar Areas
51.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11993894
SID: 17493020
ChEMBL ID
CHEMBL217843
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS