General Information of the Compound
Compound ID
CP0420182
Compound Name
1-(4-(1H-pyrrol-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
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Structure
Formula
C23H28ClFN4O
Molecular Weight
430.955
Canonical SMILES
Fc1ccc(NC(=O)N(CCN2CCCC2)C2CCC(=CC2)c2ccc[nH]2)cc1Cl
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InChI
InChI=1S/C23H28ClFN4O/c24-20-16-18(7-10-21(20)25)27-23(30)29(15-14-28-12-1-2-13-28)19-8-5-17(6-9-19)22-4-3-11-26-22/h3-5,7,10-11,16,19,26H,1-2,6,8-9,12-15H2,(H,27,30)
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InChIKey
COSMCCAKONHKTJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.373
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
51.37
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424262
ChEMBL ID
CHEMBL229350
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1969 nM
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