General Information of the Compound
Compound ID
CP0452304
Compound Name
6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-3-methylimidazo[1,2-a]pyridine-2-carbonitrile
    Show/Hide
Structure
Formula
C21H15FN4O2
Molecular Weight
374.375
Canonical SMILES
Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C#N
    Show/Hide
InChI
InChI=1S/C21H15FN4O2/c1-14-19(11-23)24-20-7-6-17(12-26(14)20)25-9-8-18(10-21(25)27)28-13-15-2-4-16(22)5-3-15/h2-10,12H,13H2,1H3
    Show/Hide
InChIKey
PYQMXUZVYLCRAF-UHFFFAOYSA-N
Physicochemical Property
logP
3.3834
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
72.32
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 89702205
ChEMBL ID
CHEMBL3769670
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS