General Information of the Compound
Compound ID
CP0416006
Compound Name
4-(2-methylpropoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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Structure
Formula
C26H31N3O2
Molecular Weight
417.553
Canonical SMILES
CC(C)COc1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)cnc2c1C
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InChI
InChI=1S/C26H31N3O2/c1-18(2)17-31-23-9-6-21(7-10-23)26(30)28-24-11-8-22-14-20(15-27-25(22)19(24)3)16-29-12-4-5-13-29/h6-11,14-15,18H,4-5,12-13,16-17H2,1-3H3,(H,28,30)
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InChIKey
ZLLKIIUCLYZWHE-UHFFFAOYSA-N
Physicochemical Property
logP
5.42612
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
54.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57522704
SID: 137280282
ChEMBL ID
CHEMBL2059411
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 4.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS